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Asparagine attenuates intestinal injury, improves energy status and inhibits AMP-activated protein kinase signalling pathways in weaned piglets challenged with Escherichia coli lipopolysaccharide

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成果类型:
期刊论文
作者:
Wang, Xiuying;Liu, Yulan*;Li, Shuang;Pi, Dingan;Zhu, Huiling;...
通讯作者:
Liu, Yulan
作者机构:
[Liu, Yulan; Leng, Weibo; Li, Shuang; Hou, Yongqing; Shi, Haifeng; Pi, Dingan; Wang, Xiuying; Zhu, Huiling] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.
通讯机构:
[Liu, Yulan] W
Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.
语种:
英文
关键词:
Asparagine;Intestine;Energy status;Weaned piglets;Lipopolysaccharide
期刊:
British Journal of Nutrition
ISSN:
0007-1145
年:
2015
卷:
114
期:
4
页码:
553-565
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31422053, 31372318, 31172222]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2013CFA029]
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
The intestine requires a high amount of energy to maintain its health and function; thus, energy deficits in intestinal mucosa may lead to intestinal damage. Asparagine (Asn) is a precursor for many other amino acids such as aspartate, glutamine and glutamate, which can be used to supply energy to enterocytes. In the present study, we hypothesise that dietary supplementation of Asn could alleviate bacterial lipopolysaccharide (LPS)-induced intestinal injury via improvement of intestinal energy status. A total of twenty-four weaned piglets were ...

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