期刊论文

Wang, Haibo

英文

NEW JOURNAL OF CHEMISTRY

1144-0546

2020

44

48

21261-21270

10.1039/d0nj04823b

This study was financially supported by the National Natural Science Foundation of China (No. 21706201, 21676208, 21376183), Wuhan Application Basic Frontier Project (No. 2019020701011478), Wuhan Morning Light Plan of Youth Science and Technology (No. 2017050304010326), Hubei Provincial Natural Science Foundation of China (No. 2018CFA030, 2019CFB252) and Innovation Team Program of Hubei province, China (No. T201208).

本校为第一且通讯机构

Collagen-polymer conjugates are being developed rapidly based on advancements in both polymer and protein science. The attachment of polymers to proteins can be achieved with the "grafting to" method or the "grafting from" method; the latter is more attractive. Although polymer-based collagen engineering provides an attractive strategy to regulate the native functions of collagen, there are still two important unresolved issues: the harsh modification conditions and the loss of fibrillogenesis property. Herein, a collagen-PNIPAAm conjugate (PCol) was prepared by the "grafting from" method to a...