This work was jointly supported by National Natural Science Foundation of China ( 32172763 , 32072762 ), Science and Technology Project of Wuhan ( 2020020602012125 ), and Hubei Provincial Key R&D Program ( 2021BBA083 , 2019ABA083 ).
机构署名：
本校为第一且通讯机构
院系归属：
动物科学与营养工程学院
摘要：
This study aimed to investigate the effect of N-acetylcysteine (NAC) on indomethacin (IDMT)-induced intestinal injury in a piglet model and explore the underlying molecular mechanisms. Piglets were randomly divided into 3 treatment groups: (1) control group; (2) IDMT group; (3) NAC+IDMT group. The results showed that NAC administration significantly increased the average daily gain of piglets, attenuated the intestine hyperemia, and restored normal jejunal morphology. Further studies indicated that NAC administration significantly increased plasma citrulline concentration and jejunal villin ex...
