Semi-rational design and modification of phosphoketolase to improve the yield of tyrosol in Saccharomyces cerevisiae

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成果类型：

期刊论文

作者：

Song, Na;Xia, Huili;Xie, Yaoru;Guo, Shuaikang;Zhou, Rong;...

通讯作者：

Chen, Xiong;Dai, J

作者机构：

[Zhou, Rong; Guo, Shuaikang; Xie, Yaoru; An, Feiran; Shangguan, Lingling; Yao, Lan; Song, Na; Dai, Jun; Zhuang, Kun; Zheng, Xueyun; Chen, Xiong; Zhang, Huiyan] Hubei Univ Technol, Cooperat Innovat Ctr Ind Fermentat, Natl Ctr Cellular Regulat & Mol Pharmaceut 111, Key Lab Fermentat Engn,Minist Educ & Hubei Prov,Hu, Wuhan 430068, Peoples R China.

[Xia, Huili] Huanghuai Univ, Coll Biol & Food Engn, Zhumadian 463000, Peoples R China.

[Zhuang, Kun] Wuhan Polytech Univ, Sch Food Sci & Engn, Wuhan 430023, Peoples R China.

[Yang, Shihui; Dai, Jun] Hubei Univ, Sch Life Sci, State Key Lab Biocatalysis & Enzyme Engn, Wuhan 430062, Hubei, Peoples R China.

[Chen, Xiong; Dai, J] Hubei Univ Technol, Sch Life & Hlth Sci, 28 Nanli Rd, Wuhan 430068, Hubei, Peoples R China.

通讯机构：

[Chen, X; Dai, J ] H

Hubei Univ Technol, Sch Life & Hlth Sci, 28 Nanli Rd, Wuhan 430068, Hubei, Peoples R China.

语种：

英文

关键词：

PHK pathway;Phosphoketolase;Tyrosol;d-Erythrose 4-phosphate

期刊：

合成和系统生物技术

ISSN：

2405-805X

年：

2025

卷：

期：

页码：

294-306

DOI：

10.1016/j.synbio.2024.11.007

基金类别：

National Natural Science Foundations of China [31871789, 41876114]; key project of Hubei Provincial Department of Education [T2022011]; Natural Science Foundation of Hubei Province [2024AFB803]

机构署名：

本校为其他机构

院系归属：

食品科学与工程学院

摘要：

Tyrosol is an important component of pharmaceuticals, nutraceuticals, and cosmetics, and their biosynthetic pathways are currently a hot research topic. d -Erythrose 4-phosphate is a key precursor for the biosynthesis of tyrosol in Saccharomyces cerevisiae . Hence, the flux of d -Erythrose 4-phosphate determined the yield of tyrosol synthesis. In this study, we first obtained an S. cerevisiae strain S19 with a tyrosol yield of 247.66 mg/L by metabolic engineering strategy. To increase the production of d -Erythrose 4-phosphate, highly active phosphoketolase BA-C was obtained by bioinformatics ...

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Semi-rational design and modification of phosphoketolase to improve the yield of tyrosol in Saccharomyces cerevisiae

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