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Safe and efficient gene delivery based on rice bran polysaccharide

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成果类型:
期刊论文
作者:
Wu, Shuheng;Ni, Danni;Yan, Yujian;Pan, Xianhu;Chen, Xin;...
通讯作者:
Liu, Liang
作者机构:
[Pan, Xianhu; Chen, Xin; Ni, Danni; Wu, Shuheng; Liu, Liang; Yan, Yujian; Xiong, Xuemin] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Hubei, Peoples R China.
[Guan, Jintao] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Hubei, Peoples R China.
通讯机构:
[Liu, Liang] W
Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Hubei, Peoples R China.
语种:
英文
期刊:
International Journal of Biological Macromolecules
ISSN:
0141-8130
年:
2019
卷:
137
页码:
1041-1049
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21602166]; Fundamental Research Funds of Wuhan Polytechnic University [2018Y13]
机构署名:
本校为第一且通讯机构
院系归属:
生命科学与技术学院
化学与环境工程学院
摘要:
Polysaccharides are capable of being modified by polycations to adjust their physical and chemical properties, which accordingly are considered as potential candidate materials for safe and efficient gene delivery. Here, we extracted and purified polysaccharides from rice bran, and their physicochemical properties were determined by various methods. Polyethyleneimine (PEI) modified rice bran polysaccharide (PRBP) was prepared by grafting RBP with low molecular weight PEI and the preparation was determined by FTIR. The potential of PRBP as a gene vector was systematically evaluated in vitro. Th...

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