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Integrated gene co-expression network analysis and experimental validation identified ITGB1 as a candidate gene affecting milk production in dairy cattle

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成果类型:
期刊论文
作者:
Deng, Tingxian;Sun, Peihao;Ma, Xiaoya;Zhou, Ji;Gong, Yaqian;...
通讯作者:
Aixin Liang
作者机构:
[Sun, Peihao; Zhou, Ji; Gong, Yaqian; Li, Xiang; Yang, Liguo] Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology , Huazhong Agricultural University, Wuhan 430070, PR China
Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming & Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, School of Animal Science and Nutritional Engineering , Wuhan Polytechnic University, Wuhan 430023, PR China
[Ma, Xiaoya] Key Laboratory of Buffalo Genetics, Breeding and Reproduction Technology, Buffalo Research Institute , Chinese Academy of Agricultural Sciences, Nanning 530001, PR China
Frontiers Science Center for Animal Breeding and Sustainable Production (Huazhong Agricultural University), Ministry of Education , Wuhan 430070, China
[Deng, Tingxian] Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology , Huazhong Agricultural University, Wuhan 430070, PR China<&wdkj&>Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming & Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, School of Animal Science and Nutritional Engineering , Wuhan Polytechnic University, Wuhan 430023, PR China<&wdkj&>Key Laboratory of Buffalo Genetics, Breeding and Reproduction Technology, Buffalo Research Institute , Chinese Academy of Agricultural Sciences, Nanning 530001, PR China
通讯机构:
[Aixin Liang] K
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology , Huazhong Agricultural University, Wuhan 430070, PR China<&wdkj&>Frontiers Science Center for Animal Breeding and Sustainable Production (Huazhong Agricultural University), Ministry of Education , Wuhan 430070, China
语种:
英文
关键词:
Gene co-expression network analysis;ITGB1;apoptosis;dairy cattle;mammary epithelial cells;proliferation
期刊:
JOURNAL OF ANIMAL SCIENCE
ISSN:
0021-8812
年:
2025
机构署名:
本校为其他机构
院系归属:
动物科学与营养工程学院
摘要:
Identification of functional genes associated with milk production is essential for establishing effective breeding programs in dairy cattle. To date, the specific functional genes involved in milk production in dairy cows remain to be identified. In this study, we used public RNA-seq data from dairy cows and employed gene co-expression network analysis to identify ITGB1 as a potential candidate gene related to lactation. In vitro assays demonstrated that ITGB1 knockdown in bovine mammary epithelial cells (MAC-T) inhibited cell proliferation, increased apoptosis, and reduced triglyceride level...

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