Integrated gene co-expression network analysis and experimental validation identified ITGB1 as a candidate gene affecting milk production in dairy cattle

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成果类型：

期刊论文

作者：

Deng, Tingxian;Sun, Peihao;Ma, Xiaoya;Zhou, Ji;Gong, Yaqian;...

通讯作者：

Liang, AX

作者机构：

[Deng, Tingxian; Liang, Aixin; Zhou, Ji; Gong, Yaqian; Li, Xiang; Zhang, Shujun; Yang, Liguo; Sun, Peihao] Huazhong Agr Univ, Coll Anim Sci & Technol, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China.

[Deng, Tingxian] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Lab Genet Breeding Reprod & Precis Livestock Farmi, Wuhan 430023, Peoples R China.

[Deng, Tingxian] Wuhan Polytech Univ, Hubei Prov Ctr Technol Innovat Domest Anim Breedin, Sch Anim Sci & Nutr Engn, Wuhan 430023, Peoples R China.

[Deng, Tingxian; Ma, Xiaoya] Chinese Acad Agr Sci, Buffalo Res Inst, Key Lab Buffalo Genet Breeding & Reprod Technol, Nanning 530001, Peoples R China.

[Liang, Aixin; Yang, Liguo] Huazhong Agr Univ, Frontiers Sci Ctr Anim Breeding & Sustainable Prod, Minist Educ, Wuhan 430070, Peoples R China.

通讯机构：

[Liang, AX ] H

Huazhong Agr Univ, Coll Anim Sci & Technol, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China.

Huazhong Agr Univ, Frontiers Sci Ctr Anim Breeding & Sustainable Prod, Minist Educ, Wuhan 430070, Peoples R China.

语种：

英文

关键词：

Gene co-expression network analysis;ITGB1;apoptosis;dairy cattle;mammary epithelial cells;proliferation

期刊：

JOURNAL OF ANIMAL SCIENCE

ISSN：

0021-8812

年：

2025

卷：

103

DOI：

10.1093/jas/skaf239

基金类别：

Fundamental Research Funds for the Central Universities [2662025DKPY008]; National Natural Science Foundation of China [32272876]

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

Identification of functional genes associated with milk production is essential for establishing effective breeding programs in dairy cattle. To date, the specific functional genes involved in milk production in dairy cows remain to be identified. In this study, we used public RNA-seq data from dairy cows and employed gene co-expression network analysis to identify the integrin beta 1 (ITGB1) as a potential candidate gene related to lactation. In vitro assays demonstrated that ITGB1 knockdown in bovine mammary epithelial cells (MAC-T) inhibited cell proliferation, increased apoptosis, and redu...

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Integrated gene co-expression network analysis and experimental validation identified ITGB1 as a candidate gene affecting milk production in dairy cattle

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