期刊论文

Liu, Yulan

英文

INNATE IMMUNITY

1753-4259

2021

27

2

170-183

10.1177/1753425920983869

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was funded by the National Natural Science Foundation of China (31702203), the Project of Innovative Research Groups of the Natural Science Foundation of Hubei Province (2019CFA015), Natural Science Foundation of Hubei Province (2018CFB535), Frontier Program for Applied and Basic Research of Wuhan, China (2019020701011494), the Major Program of Technology Innovation of Hubei Province (2019ABA084) and the Open Project of Hubei Key Laboratory of Animal Nutrition and Feed Science (DKXY2020003) and The National Natural Science; Foundation of Hubei Province (No. 2018CFB527).

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Long non-coding RNAs (lncRNAs) are emerging as key regulators in inflammation. However, their functions and profiles in LPS-induced inflammation in pigs are largely unknown. In this study, we profiled global lncRNA and mRNA expression changes in PBMCs treated with LPS using the lncRNA-seq technique. In total 43 differentially expressed (DE) lncRNAs and 1082 DE mRNAs were identified in porcine PBMCs after LPS stimulation. Functional enrichment analysis on DE mRNAs indicated these genes were involved in inflammation-related signaling pathways, in...