Attenuation of Gouty Arthritis by Emodinol in Monosodium Urate Crystal-Treated Mice

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成果类型：

期刊论文

作者：

Chen, Lvyi*;Lan, Zhou;Ma, Shuwei;Zhao, Ling;Yang, Xinzhou

通讯作者：

Chen, Lvyi

作者机构：

[Yang, Xinzhou; Chen, Lvyi] South Cent Univ Nationalities, Sch Pharm, Wuhan 430074, Peoples R China.

[Lan, Zhou] China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Nanjing, Jiangsu, Peoples R China.

[Ma, Shuwei] Qiqihar Univ, Inst Chem & Chem Engn, Qiqihar, Peoples R China.

[Zhao, Ling] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Peoples R China.

[Chen, Lvyi] South Cent Univ Nationalities, Sch Pharm, 708 Min Zu Rd, Wuhan 430074, Peoples R China.

通讯机构：

[Chen, Lvyi] S

South Cent Univ Nationalities, Sch Pharm, 708 Min Zu Rd, Wuhan 430074, Peoples R China.

语种：

英文

关键词：

Elaeagnus pungens;Elaeagnaceae;emodinol;gouty arthritis;interleukin 1 beta;monosodium urate crystals

期刊：

PLANTA MEDICA

ISSN：

0032-0943

年：

2013

卷：

期：

页码：

634-638

DOI：

10.1055/s-0032-1328430

基金类别：

Chinese National Project of "Twelfth Five-Year" Plan for Science & Technology Support [2012BAI27B06]; Special Fund for Basic Scientific Research of Central Colleges, South-Central University for Nationalities [CZQ11035]

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

A series of studies have recently demonstrated that the release of interleukin 1β induced by monosodium urate crystals is central to the experimental gouty arthritis. Elaeagnus pungens has been traditionally used for the treatment of gouty arthritis in China for more than thousands years. However, there is still little known about the active ingredients and mechanisms of E. pungens against gouty arthritis. Emodinol, as a major triterpene compound in E. pungens, has been seldom reported to have an effect on gouty arthritis. Therefore, th...

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