Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated from South-central in China

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成果类型：

期刊论文

作者：

Yu, Xiao-li;Wen, Zi-lu;Chen, Gao-zhan;Li, Rui;Ding, Bing-bing;...

通讯作者：

Zhang, Shu-lin

作者机构：

[Li, Rui; Ding, Bing-bing; Wen, Zi-lu; Yu, Xiao-li; Chen, Gao-zhan] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Peoples R China.

[Zhang, Shu-lin; Yao, Yu-feng; Guo, Xiao-kui; Wen, Zi-lu; Yu, Xiao-li] Shanghai Jiao Tong Univ, Sch Med, Dept Med Microbiol & Parasitol, Shanghai 20025, Peoples R China.

[Wang, Hong-hai; Li, Yao; Wu, Hai] Fudan Univ, Inst Genet, State Key Lab Genet Engn, Shanghai 200433, Peoples R China.

通讯机构：

[Zhang, Shu-lin] S

Shanghai Jiao Tong Univ, Sch Med, Dept Med Microbiol & Parasitol, Shanghai 20025, Peoples R China.

语种：

英文

关键词：

isoniazid;rifampicin;RNA 16S;spacer DNA;allele;article;China;controlled study;gene mutation;gene sequence;genetic marker;genotype;Mycobacterium tuberculosis;nonhuman;nucleotide sequence;phenotype;priority journal;promoter region;Academic Medical Centers;Alleles;Amino Acid Substitution;Antitubercular Agents;Bacterial Proteins;Catalase;China;DNA, Intergenic;Drug Resistance, Multiple, Bacterial;Extensively Drug-Resistant Tuberculosis;Humans;Isoniazid;Microbial Sensitivity Tests;Molecular Typing;Mutation;Mycobacterium tuberculosis;Prevalence;Promoter Regions, Genetic;Rifampin;Tuberculosis, Pulmonary

期刊：

JOURNAL OF ANTIBIOTICS

ISSN：

0021-8820

年：

2014

卷：

期：

页码：

291-297

DOI：

10.1038/ja.2013.133

基金类别：

This work was supported by grants 2012ZX10003002-002 and 2013ZX10003002-005 from China Mega-Projects of Science Research for the 12th Five Year Plan, Grant D20121809 from Educational Commission of Hubei, China, Grant 12441903300 from the Science and Technology Commission of Shanghai Municipality, and grant 2010CX016 from Graduate Innovation Foundation of Wuhan Polytechnic University.

机构署名：

本校为第一机构

院系归属：

生命科学与技术学院

摘要：

Rifampicin (RIF) and isoniazid (INH) Mycobacterium tuberculosis isolates were characterized from South-central China and transmission patterns within the Beijing genotype were detected in multidrug-resistant isolates. Six genetic regions, including rpoB for RIF, and katG, inhA, ahpC, mabA-inhA promoter and oxyR-ahpC intergenic region for INH were analyzed by DNA sequencing in 60 multidrug-resistant isolates, including 7 extensively drug-resistant isolates. The genomic deletion RD105 was characterized by genotyping. The results showed that 91.7%...

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Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated from South-central in China

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