Asparagine reduces the mRNA expression of muscle atrophy markers via regulating protein kinase B (Akt), AMP-activated protein kinase α, toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling in weaning piglets after lipopolysaccharide challenge

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Xiuying;Liu, Yulan*;Wang, Shuhui;Pi, Dingan;Leng, Weibo;...

通讯作者：

Liu, Yulan

作者机构：

[Zhang, Jing; Liu, Yulan; Leng, Weibo; Shi, Haifeng; Li, Shuang; Wang, Shuhui; Pi, Dingan; Wang, Xiuying; Zhu, Huiling] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Odle, Jack; Lin, Xi] North Carolina State Univ, Dept Anim Sci, Lab Dev Nutr, Raleigh, NC 27695 USA.

通讯机构：

[Liu, Yulan] W

Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Asparagine;Lipopolysaccharides;Muscle atrophy;Pro-inflammatory cytokines

期刊：

British Journal of Nutrition

ISSN：

0007-1145

年：

2016

卷：

116

期：

页码：

1188-1198

DOI：

10.1017/S000711451600297X

基金类别：

The present study was supported by the National Natural Science Foundation of China (grant no. 31422053 and 31372318), and the Project of the Hubei Provincial Department of Education (grant no. T201508).

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Pro-inflammatory cytokines are critical in mechanisms of muscle atrophy. In addition, asparagine (Asn) is necessary for protein synthesis in mammalian cells. We hypothesised that Asn could attenuate lipopolysaccharide (LPS)-induced muscle atrophy in a piglet model. Piglets were allotted to four treatments (non-challenged control, LPS-challenged control, LPS+0·5 % Asn and LPS+1·0 % Asn). On day 21, the piglets were injected with LPS or saline. At 4 h post injection, piglet blood and muscle samples were collected. Asn increased protein and RNA ...

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Asparagine reduces the mRNA expression of muscle atrophy markers via regulating protein kinase B (Akt), AMP-activated protein kinase α, toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling in weaning piglets after lipopolysaccharide challenge

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