Insights into the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-induced gelation of fully carboxylated collagen and the fabrication of hydrogels with enhanced mechanical properties

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成果类型：

期刊论文

作者：

Zhang, Juntao;Xu, Haofei;Liu, Yang;Sui, Peishan;Deng, Fen;...

通讯作者：

Wang, HB

作者机构：

[Deng, Fen; Xu, Chengzhi; Sui, Peishan; Wei, Benmei; Liu, Yang; Liu, Tianyi; Xu, Haofei; Zhang, Juntao; Zheng, Mingming] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan, Hubei, Peoples R China.

[Wang, Haibo] Hubei Engn Univ, Coll Life Sci & Technol, Hubei Key Lab Qual Control Characterist Fruits & V, Xiaogan, Hubei, Peoples R China.

[Zheng, Mingming] Oil Crops Res Inst, Chinese Acad Agr Sci, Key Lab Oilseeds Proc, Minist Agr,Hubei Key Lab Lipid Chem & Nutr, Wuhan, Hubei, Peoples R China.

通讯机构：

[Wang, HB ] H

Hubei Engn Univ, Coll Life Sci & Technol, Hubei Key Lab Qual Control Characterist Fruits & V, Xiaogan, Hubei, Peoples R China.

语种：

英文

期刊：

NEW JOURNAL OF CHEMISTRY

ISSN：

1144-0546

年：

2024

卷：

期：

页码：

6660-6669

DOI：

10.1039/D4NJ00362D

基金类别：

National Natural Science Foundation of China [22378320, 22178277, 21706201]; National Natural Science Foundation of China [2023020201010148]; Knowledge Innovation Program of Wuhan-Basi Research [2019020701011478]; Application Foundation Frontier Project of Wuhan Science and Technology Bureau

机构署名：

本校为第一机构

院系归属：

化学与环境工程学院

摘要：

Collagen-based hydrogels have been widely used as biomaterials in recent years owing to their excellent biological properties. However, their poor mechanical properties due to the poor solubility of native collagen under physiological conditions limit their application. In this case, although the solubility of collagen can be improved by succinylation, the gelation of succinylated collagen (SCol) is another challenge. Herein, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) was used to induce the gelation of SCol based on the formation of anhydride bonds between the carboxyl groups of SCol...

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Insights into the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-induced gelation of fully carboxylated collagen and the fabrication of hydrogels with enhanced mechanical properties

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