期刊论文

中文

中国畜牧杂志

0258-7033

2010

46

3

15-19

国家自然科学基金面上项目（30500362和30972109） 教育部科学技术研究重点项目（209082）

本校为第一机构

试验研究罗格列酮(ROS)对脂多糖(LPS)刺激的断奶仔猪肠黏膜结构和抗氧化能力的影响.试验包括3个处理组,对照组注射生理盐水,LPS组注射100 μg/kg体重的LPS,ROS组在注射LPS之前的30 min注射3 mg/kg体重的RPS.注射LPS 3 h后取样.结果表明:ROS提高了十二指肠和回肠DNA的含量(p＜O.05);ROS缓解了LPS导致的十二指肠、空肠和回肠隐窝深度的增加(p＜0.10)和绒毛高度/隐窝深度的降低(p＜0.01);ROS降低了空肠丙二醛含量(P＜0.10),提高了十二指肠和空肠SOD活性(P＜0.05).结果表明,ROS可能是通过提高肠道抗氧化功能而对LPS刺激的断奶仔猪小肠形态结构的损伤起到一定保护作用.

This experiment was conducted to determine the effect of rosiglitazone（ROS） on intestinal morphology and antioxidant ability in weaned pigs after Escherichia coli lipopolysaccharide（LPS） challenge.Piglets were allotted to three treatments including：control group;LPS-challenged group（LPS）;ROS ＋ LPS group（ROS）.Pigs were injected with 100 μg/kg BW of LPS or sterile saline.ROS or its vehicle was given 30 min before LPS injection.At 3 h following injection of LPS,pigs were sacrificed and small intestin samples were collected.The results s...