期刊论文

Effect of Aspartate on Colonic Morphology and Barrier Function in Piglets with Lipopolysaccharide Challenge

中文

中国畜牧杂志

0258-7033

2015

51

01

38-42

10.3969/j.issn.0258-7033.2015.01.009

教育部新世纪优秀人才支持计划(NCET-10-0158)； 国家自然科学基金面上项目(31172222； 31372318)； 湖北省自然科学基金***人才项目(2013CFA029)； 湖北省国际科技合作项目(2011BFA008)；

本校为第一机构

本试验旨在研究天冬氨酸(ASP)对脂多糖(LPS)刺激仔猪结肠黏膜结构和屏障功能的影响。试验选用24头仔猪,4个处理组分别为对照组、LPS组、0.5%ASP组、1.0%ASP组。试验第19天,分别给LPS组、0.5%ASP组、1.0%ASP组试验猪注射100μg/kg体重的LPS,对照组注射等量的生理盐水。注射后24 h屠宰,取结肠样品待测。结果表明:对照组仔猪结肠形态结构完整;注射LPS后,结肠上皮部分脱落;ASP组轻度脱落,与LPS组相比,0.5%ASP组结肠隐窝深度显著升高(P

The study was conducted to evaluate the effects of aspartate （ASP） supplementation on colonic morphology and mucosal barrier function in piglets with lipopolysaccharide （LPS） challenge. Twenty-four piglets were randomly assigned into 4 groups： control; LPS; 0.5% ASP; 1.0% ASP. The trial period was 19 days. On day 19, the piglets in the LPS group, 0.5% ASP group and 1.0% ASP group were injected with 100 μg/kg BW LPS, and the piglets in the control group were injected with the same dose of sterile saline. After 24 h saline or LPS injection,...