期刊论文

Advances in Regulation of PLINs Gene on Lipids and Its Potential Breeding Value

中文

中国畜牧杂志

0258-7033

2023

59

06

27-35

10.19556/j.0258-7033.20220719-05

2021YFA0805901-4:国家重点研发计划 XDA24030204:中国科学院战略性先导科技专项 2022-620-000-001-20:湖北省农业科技创新中心项目

本校为第一机构

周脂素蛋白家族（Perilipins,PLINs）有PLIN1、PLIN2、PLIN3、PLIN4和PLIN5 5种蛋白，该蛋白家族定位于脂滴（Lipid Droplets,LDs）表面，与其他分子相互作用介导脂质的合成与分解。PLIN1可调控脂肪的蓄积，也是脂肪细胞分化的标志物之一。PLIN2是脂质蓄积最重要的调节因子之一，可促进脂质合成，抑制LDs中主要脂质甘油三酯（Triglycerides,TG）和胆固醇酯（Cholesterol Ester,CE）的分解。PLIN3是中性脂质形成的关键基因。PLIN4参与脂肪细胞分化，还可修补脂滴形态的缺陷。PLIN5在LD积累与缓解脂毒性中起关键作用。本文综述了近年关于PLINs家族调控脂质的研究现状及其在畜禽上的应用，旨在阐述...

The perilipin family of proteins(perilipins,PLINs)consists of five proteins,PLIN 1,PLIN 2,PLIN 3,PLIN 4 and PLIN 5.PLINs are localized on the surface of lipid droplets(LDs)and mediate the lipids synthesis and lipolysis by interacting with other molecules.As one of the m...MORE The perilipin family of proteins(perilipins,PLINs)consists of five proteins,PLIN 1,PLIN 2,PLIN 3,PLIN 4 and PLIN 5.PLINs are localized on the surface of lipid droplets(LDs)and mediate the lipids synthesis and lipolysis by interacting with other molecules.As one of the markers of adipocyte differentiation,PLIN 1 has been ...