Necroptosis Mediates Muscle Protein Degradation in a Cachexia Model of Weanling Pig with Lipopolysaccharide Challenge

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Guo, Junjie;Qin, Xu;Wang, Yang;Li, Xiangen;Wang, Xiuying;...

通讯作者：

Xiao, Kan;Liu, YL

作者机构：

[Wang, Yang; Liu, Yulan; Xiao, Kan; Chen, Shaokui; Guo, Junjie; Li, Xiangen; Liu, YL; Wang, Xiuying; Qin, Xu; Zhu, Huiling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Zhao, Jiangchao] Univ Arkansas, Dept Anim Sci, Div Agr, Fayetteville, AR 72701 USA.

[Liu, Yulan; Xiao, Kan; Liu, YL] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, 68 Xuefu South Rd, Wuhan 430023, Peoples R China.

通讯机构：

[Xiao, K; Liu, YL ] W

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, 68 Xuefu South Rd, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

necroptosis;cachexia;pro-inflammatory cytokines;protein degradation

期刊：

International Journal of Molecular Sciences

ISSN：

1661-6596

年：

2023

卷：

期：

页码：

10923-

DOI：

10.3390/ijms241310923

基金类别：

This work was supported by the National Natural Science Foundation of China (32272906 and U22A20517).

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Necroptosis, an actively researched form of programmed cell death closely related to the inflammatory response, is important in a variety of disorders and diseases. However, the relationship between necroptosis and muscle protein degradation in cachexia is rarely reported. This study aimed to elucidate whether necroptosis played a crucial role in muscle protein degradation in a cachexia model of weaned piglets induced by lipopolysaccharide (LPS). In Experiment 1, the piglets were intraperitoneally injected with LPS to construct the cachexia model, and sacrificed at different time points after ...

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Necroptosis Mediates Muscle Protein Degradation in a Cachexia Model of Weanling Pig with Lipopolysaccharide Challenge

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