期刊论文

He, Yi;Wang, ZQ

英文

International Journal of Biological Macromolecules

0141-8130

2023

240

124442

10.1016/j.ijbiomac.2023.124442

This research was supported by The National Natural Science Foundation of China (Grant No. 31900011), Ganzhou General Inspection and Testing Institute (Grant No. GZSZJYKF-202209), Research and Innovation Initiatives of WHPU, Technical Reserve Project from School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University & Enshi Se-Run Material Engineering Technology Co., Ltd. (No. Sel202104). CRediT authorship contribution statement Chao Gao: Conceptualization, Investigation, Writing – original draft, Formal analysis. Jieya Deng: Investigation, Writing – original draft, Formal analysis. Naureen Anwar: Writing – original draft. Muhammad Umer: Writing – original draft. Jixin Chen: Investigation. Qiao Wu: Writing – original draft. Xingxing Dong: Resources. Hua Xu: Resources. Yi He: Conceptualization, Resources, Writing – review & editing, Project administration, acquisition. Zhangqian Wang: Conceptualization,

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G-quadruplexes are widely distributed in cells and are usually essential in mediating biological processes. The intracellular environment is often in a state of molecular crowding, and the current research considerably focuses on the effect of molecular crowding on the conformation of telomeric G-quadruplexes. However, G-quadruplex-forming oligonucleotides are primarily located in the promoter region of the proto-oncogene and on mRNA inside the cell and are reported to fold into parallel structures. Thus, studying the interaction mechanism between ligands and parallel structured G-quadruplexes...