Impact of diethylhexyl phthalate on gene expression and development of mammary glands of pregnant mouse

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成果类型：

期刊论文

作者：

Li, Lan;Liu, Jing-Cai;Zhao, Yong;Lai, Fang-Nong;Yang, Fan;...

通讯作者：

Zhang, Xi-Feng

作者机构：

[Chen, Hong; Li, Lan] Northwest A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Mol Biol Agr, Yangling 712100, Shaanxi, Peoples R China.

[Liu, Jing-Cai; Lai, Fang-Nong; Yang, Fan; Ge, Wei; Zhao, Yong; Shen, Wei; Dou, Cheng-Li] Qingdao Agr Univ, Shandong Univ, Coll Anim Sci & Technol, Inst Reprod Sci,Key Lab Anim Reprod & Germplasm E, Qingdao 266109, Peoples R China.

[Liu, Jing-Cai; Lai, Fang-Nong; Yang, Fan] Qingdao Agr Univ, Coll Life Sci, Qingdao 266109, Peoples R China.

[Zhao, Yong] Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China.

[Zhang, Xi-Feng] Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.

通讯机构：

[Zhang, Xi-Feng] W

Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

DEHP;Mammary gland;Gene expression pattern;Microarray

期刊：

Histochemistry and Cell Biology

ISSN：

0948-6143

年：

2015

卷：

144

期：

页码：

389-402

DOI：

10.1007/s00418-015-1348-9

基金类别：

National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31201120]; Nature Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2011CDB230]; Nature Science Foundation of Heilongjiang ProvinceNatural Science Foundation of Heilongjiang Province [ZD201304]

机构署名：

本校为通讯机构

院系归属：

生命科学与技术学院

摘要：

The widely used diethylhexyl phthalate (DEHP) is a known endocrine disruptor that causes persistent alterations in the structure and function of female reproductive system, including ovaries, uterus and oviducts. To explore the molecular mechanism of the effect of DEHP on the development of mammary glands, we investigated the cell cycle, growth, proliferation and gene expression of mammary gland cells of pregnant mice exposed to DEHP. It was demonstrated, for the first time, that the mammary gland cells of pregnant mice treated with DEHP for 0.5-3.5 days post-coitum had increased proliferation...

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Impact of diethylhexyl phthalate on gene expression and development of mammary glands of pregnant mouse

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