Flupyradifurone is a novel butenolide insecticide widely applied to control a broad range of sucking pests, including Myzus persicae . However, resistance monitoring has revealed that several Chinese populations have developed moderate resistance to flupyradifurone. Therefore, we investigated the risk and underlying mechanisms of flupyradifurone resistance in M. persicae . A flupyradifurone-resistant strain (FDF-R) was established through 14 generations of selection and exhibited a 35.02-fold increase in resistance. FDF-R showed cross-resistance to acetamiprid (13.9-fold), sulfoxaflor (3.5-fol...
