Three water-soluble hetero-polysaccharides, designated LP1–3, were isolated from litchi pulp. Their structures, solution properties and immunomodulatory activities were evaluated. LP1 contained (1 → 4,6)-β-D-Glc and (1 → 4)-α-L-Gal, while LP2 contained (1 → 3)-α-L-Ara and (l → 2)-β-D-Gal, and LP3 contained α-L-Ara and (l → 4)-β-Rha. Their molecular weights ranged from 105,880 to 986,470 g/mol. LP1 had a spherical conformation with hyper-branched structure and LP2 was semi-flex...