期刊论文

中文

南通大学学报(医学版)

1674-7887

2003

23

3

262-263,265

10.3969/j.issn.1674-7887.2003.03.012

本校为第一机构

目的:建立再狭窄动物实验模型.方法:采用右髂动脉球囊内皮剥落术加高胆固醇喂饲家兔.结果:经血管造影检查,右髂动脉平均狭窄程度血管成形术前在60%以上,术后5周在50%以上;病理切片和组织生化显示内膜明显增厚,可见大量泡沫细胞,脂质沉积显著增加;透射电镜和免疫组织化学鉴定显示,增生内膜主要是平滑肌细胞增殖.结论:采用本方法可以成功地建立再狭窄动物模型,增生的内膜主要是平滑肌细胞增殖.

Objective:Setting up the experimental animal model of restenosis.Method:To use the endothlium peeling technique through the right iliac artery and to feed the rabbits with high cholesterol.Results:Inspect by angiography,the stenosis degree of the right iliac artery is over 60% febore the angioplasty.The steosis degree of the right iliac artery is over 50% after angioplasty.Pathological and histological results show that thickness of endothelium is increased and large quantities of the foaming cell can be seen,lipid deposit increased obviously;electro-microscope and immuno-histo-chemistry resul...