Reaction of human telomeric unit TTAGGG and a photoactivatable Pt(iv) anticancer prodrug

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成果类型：

期刊论文

作者：

Lin, Jiafan;Zhang, Jishuai;Ma, Ziqi;Wu, Xiaoqin;Wang, Fuyi;...

通讯作者：

Wu, Kui;Liu, Y;Zhao, Y

作者机构：

[Lin, Jiafan; Zhang, Jishuai; Ma, Ziqi; Liu, Yi; Wu, Xiaoqin; Wu, Kui] Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Hubei Prov Coal Convers & New Carbon Mat, Wuhan 430081, Peoples R China.

[Lin, Jiafan; Zhang, Jishuai; Wang, Fuyi; Zhao, Yao] Chinese Acad Sci, Inst Chem, Natl Ctr Mass Spectrometry Beijing, Beijing Natl Lab Mol Sci,CAS Key Lab Analyt Chem L, Beijing 100190, Peoples R China.

[Wang, Fuyi] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

[Liu, Yi] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.

[Wu, Kui; Liu, Yi] Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Hubei Prov Coal Convers & New Carbon Mat, Wuhan 430081, Peoples R China.

通讯机构：

[Wu, K; Liu, Y ; Zhao, Y ]

Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Hubei Prov Coal Convers & New Carbon Mat, Wuhan 430081, Peoples R China.

Chinese Acad Sci, Inst Chem, Natl Ctr Mass Spectrometry Beijing, Beijing Natl Lab Mol Sci,CAS Key Lab Analyt Chem L, Beijing 100190, Peoples R China.

Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.

语种：

英文

期刊：

DALTON TRANSACTIONS

ISSN：

1477-9226

年：

2023

卷：

期：

页码：

12057-12066

DOI：

10.1039/d3dt01643a

基金类别：

Wuhan University of Science and Technology [040274]; Department of Education of Hubei Province [B2022021]; Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials (Wuhan University of Science and Technology) [WKDM202304]; Hubei Key Laboratory of Bioinorganic Chemistry amp; Materia Medica [BCMM202305]; Beijing Natural Science Foundation [2232034]; National Natural Science Foundation of China [21927804]

机构署名：

本校为通讯机构

院系归属：

化学与环境工程学院

摘要：

The interaction of a photoactivatable diazidodihydroxido Pt(IV) prodrug, trans,trans,trans-[Pt(N(3))(2)(OH)(2)(py)(2)] (py = pyridine; 1), with a hexamer straight human telomeric DNA unit sequence (5'-T(1)T(2)A(3)G(4)G(5)G(6)-3', I) upon light irradiation was investigated by electrospray ionization mass spectroscopy (ESI-MS). In the primary mass spectrum, two major mono-platinated I adducts with the bound Pt moieties, trans-[Pt(II)(N(3))(py)(2)](+) (1') and trans-[Pt(II)(py)(2)](2+) (1''), respectively, were detected. It is rare to observe such high abundance and nearly equal intensity platina...

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Reaction of human telomeric unit TTAGGG and a photoactivatable Pt(iv) anticancer prodrug

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