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ECR-MAPK Regulation in Liver Early Development

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成果类型:
期刊论文
作者:
Zhao, Xiu-Ju*赵秀举);Zhuo, Hexian
通讯作者:
Zhao, Xiu-Ju(赵秀举
作者机构:
[Zhao, Xiu-Ju] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Collaborat Innovat Ctr Proc Agr Prod Hubei Prov, Wuhan 430023, Peoples R China.
[Zhao, Xiu-Ju] Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China.
[Zhuo, Hexian] Xinxiang Inst Drug Control, Xinxiang 453000, Peoples R China.
[Zhao, Xiu-Ju] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Collaborat Innovat Ctr Proc Agr Prod Hubei Prov, 68 South Xuefu Rd, Wuhan 430023, Peoples R China.
通讯机构:
[Zhao, Xiu-Ju] W
Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Collaborat Innovat Ctr Proc Agr Prod Hubei Prov, 68 South Xuefu Rd, Wuhan 430023, Peoples R China.
语种:
英文
期刊:
BioMed Research International
ISSN:
2314-6133
年:
2014
卷:
2014
页码:
850802
基金类别:
Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2012FFB04802]; Wuhan Polytechnic University [2012RZ06]
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
生命科学与技术学院
摘要:
Early growth is connected to a key link between embryonic development and aging. In this paper, liver gene expression profiles were assayed at postnatal day 22 and week 16 of age. Meanwhile another independent animal experiment and cell culture were carried out for validation. Significance analysis of microarrays, qPCR verification, drug induction/inhibition assays, and metabonomics indicated that alpha-2u globulin (extracellular region)-socs2 (-SH2-containing signals/receptor tyrosine kinases)-ppp2r2a/pik3c3 (MAPK signaling)-hsd3b5/cav2 (metabolism/organization) plays a vital role in early de...

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