Fish oil alleviates circadian bile composition dysregulation in male mice with NAFLD

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成果类型：

期刊论文

作者：

Liu, Yang;Li, Qi;Wang, Hualin*;Zhao, Xiuju（赵秀举）;Li, Na;...

通讯作者：

Wang, Hualin

作者机构：

[Zhao, Xiuju; Wang, Hualin; Li, Qi; Liu, Zhiguo; Li, Na; Liu, Yang; Zhang, Hongyu] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Hubei Prov Engn Res Ctr Hlth Food, Wuhan 430023, Hubei, Peoples R China.

[Chen, Guoxun] Univ Tennessee, Dept Nutr, Knoxville, TN 37996 USA.

通讯机构：

[Wang, Hualin] W

Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Hubei Prov Engn Res Ctr Hlth Food, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

acetylcarnitine;aconitic acid;alanine;arginine;aspartic acid;bile acid;dextro glutamic acid;dicarboxylic acid;fish oil;glutamine;glyoxylic acid;high density lipoprotein cholesterol;histidine;homoserine;hypotaurine;kynurenine;lauric acid;linolenic acid;phenylalanine;proline;sebacic acid;starch;sucrose;taurine;tryptophan;tyrosine;bile acid;fish oil;amino acid metabolism;animal experiment;animal model;animal tissue;Article;bile acid synthesis;bile composition;C57BL 6 mouse;circadian rhythm;controlled study;dietary supplement;down regulation;fatty acid oxidation;fatty acid synthesis;high density lipoprotein cholesterol level;lipid diet;lipid storage;liquid chromatography-mass spectrometry;liver hypertrophy;liver tissue;male;metabolomics;mouse;nonalcoholic fatty liver;nonhuman;obesity;protein expression;retention time;sucrose metabolism;time of flight mass spectrometry;upregulation;Western blotting;adverse event;animal;C57BL mouse;drug effect;liver;metabolism;multivariate analysis;nonalcoholic fatty liver;pathology;signal transduction;sleep disorder;Animals;Bile Acids and Salts;Chronobiology Disorders;Diet, High-Fat;Dietary Supplements;Fish Oils;Liver;Male;Mice, Inbred C57BL;Multivariate Analysis;Non-alcoholic Fatty Liver Disease;Signal Transduction

期刊：

JOURNAL OF NUTRITIONAL BIOCHEMISTRY

ISSN：

0955-2863

年：

2019

卷：

页码：

53-62

DOI：

10.1016/j.jnutbio.2019.03.005

基金类别：

The authors would like to thank Yang Shao, Yazheng Cai for their helpful assistance with experiment. This study was supported by National Natural Science Foundation of China (Grant no. 31271855 and 81,402,669), Hubei Provincial Natural Science Foundation of China (Grant no.2017CFB275 and 2017CFB479) and the Scientific Research Project of Hubei Provincial Department of Education (B2017079).

机构署名：

本校为第一且通讯机构

院系归属：

生命科学与技术学院

摘要：

Our previous studies have found that fish oil rich in omega-3 polyunsaturated fatty acids (omega-3 PUFA) protects against non-alcoholic fatty liver disease (NAFLD) in mice. This study was aimed to explore the effects of fish oil on high fat diet (HFD)-induced circadian bile composition chaos. Male C57BL/6 mice were randomly divided into three groups, a control group (CON), a HFD group and a fish oil (FO) group, which were fed a normal chow diet, a HFD, and a HFD supplemented with FO, respectively for 12 weeks. At the end of the experiment, liver tissue, blood and bile samples were processed at...

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Fish oil alleviates circadian bile composition dysregulation in male mice with NAFLD

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