期刊论文

中文

武汉轻工大学学报

2095-7386

2015

3

25-30

10.3969/j.issn.2095-7386.2015.03.006

国家自然科学基金项目（31371783）； 国家粮食公益性行业科研专项（201313007）；

本校为第一机构

探讨高脂血症小鼠血清脂肪酸水平的变化。以高脂血症小鼠为模型,以生化检测指标为基础,通过GC—MS检测技术监测基础组、高脂组及配方油脂干预组小鼠血清脂肪酸的差异。将50只SPF级KM系雄性小鼠随机分为基础组、高脂组、配方油低中高剂量组。连续喂养4周,提取小鼠血清,检测血清生化指标,并使用气相色谱—质谱联用技术检测其脂肪酸的种类与含量。结果表明,成功建立高脂血症小鼠模型,且小鼠血清脂肪酸种类并无差别;而与基础组比较,高脂组C14∶0、C16∶1、C18∶1、C22∶6的含量有显著性差异;与高脂组相比,配方油组各脂肪酸含量均有不同程度变化,其中C16∶1、C18∶1、C22∶6的含量变化趋势显著（P〈0...

To explore the differences of serum free fatty acids ( FFA) of hyperlipidemia .Based on the hyperlipidemia model , the biochemical detection index , looking at the differences of serum fatty acids of group , fat group , formula oil low, medium, high dose groups.After continuously feeding four weeks, the serum was taken, the biochemical indexes were detected and the content of fatty acids were detected with gas chromatography-mass spectrometry .The results showed that the model of hyperlipidemia was successfully established and there was no spec...