期刊论文

Regulatory effects of astaxanthin on bile components in mice fed with high fat and high cholesterol

中文

武汉轻工大学学报

2095-7386

2019

38

2

21-24,30

10.3969/j.issn.2095-7386.2019.02.004

本校为第一机构

研究虾青素对高脂高胆固醇饲喂小鼠胆汁成分的调节作用.采用高脂高胆固醇饲喂小鼠模型,设置高脂高胆固醇饲喂组、高脂高胆固醇添加虾青素组,12周后测定小鼠血浆总甘油三酯(TG)、总胆固醇(TC),HE染色观察肝组织形态学变化,LC-MS测定胆汁组成.结果 显示:高脂高胆固醇饮食增补虾青素能够降低小鼠脂肪指数、血浆TG和TC;此外,高脂高胆固醇饮食小鼠在添加虾青素后胆汁部分成分有明显变化,其中高脂所致的组氨醇、组氨酸等成分有所改善.结论:添加虾青素能够对高脂高胆固醇饮食小鼠胆汁成分起到明显调节作用.

To study the effect of astaxanthin on the composition of bile in mice fed with high fat and high cholesterol. The mice model was fed with high fat and high cholesterol, and the high fat and high cholesterol supplemented with astaxanthin. After 12 weeks, the plasma total triglyceride (TG) total cholesterol (TC) was measured. Liver tissue morphology was observed by HE staining and bile composition was measured by LC-MS. The results showed that astaxanthin supplementation with high fat and high cholesterol diet could decrease the fat index, plasma TG and TC in mice. In addition, some components o...