Biomarkers of serum fatty acids in lipid-lowering model of pumpkin seed oil need to be elucidated. 36 SPF KM male mice were randomly divided into 3 groups,control, high-fat, PSO intervention. After continuously feeding four weeks, the content of serum fatty acids were detected with gas chromatography-mass spectrometry. No species differences existed in all these groups. The contents of C16:1 ,C18:1 ,C18:2,C22:6 were significantly different between these groups(p〈0.05). Thus the oil adjusted the serum fatty acid profile of hyper...