期刊论文

Research progress of n-3 polyunsaturated fatty acids and the endoplasmic re-ticulum stress in non-alcoholic fatty liver disease

中文

食品安全质量检测学报

2095-0381

2013

4

1234-1238

10.19812/j.cnki.jfsq11-5956/ts.2013.04.056

(31271855):国家自然科学基金项目 (D20121808):湖北省教育厅重点计划项目 (2012FFB04802):湖北省自然科学基金 (31271855):Supported by the National Natural Science Foundation of China (D20121808):Hubei Ministry of Education key project (2012FFB04802):Natural Science Foundation of Hubei Province of China

本校为第一机构

　　非酒精性脂肪性肝病(nonalcoholic fatty liver disease, NAFLD)已逐渐成为一个全球性健康问题,但其发病的具体机制不甚明朗。内质网是细胞内蛋白质加工、脂质合成和钙储存的主要场所,内质网结构和功能的失常所致的内质网应激(endoplasmic reticulum stress, ERS)对脂代谢和细胞功能具有重要调控作用,可能是NAFLD 的发生和发展的重要机制。近来大量研究显示,脂类中特定的脂质负荷(饱和脂肪酸、胆固醇)可能是诱导ERS导致NAFLD重要原因,而另一方面, n-3多不饱和脂肪酸(n-3 polyunsaturated fatty acids, n-3 PUFA)的摄入量却与NAFLD患病率呈负相关。本文就脂肪酸与内质网应激及其与NAFLD的联系...

Non-alcoholic fatty liver disease (NAFLD) is a worldwide public health problem. The underly-ing causes of NAFLD are unclear. Endoplasmic reticulum is the main site of protein processing, lipid synthesis and storage of calcium. Disruption of Endoplasmic reticulum homeostasis, which often induces endoplasmic reticulum stress (ERS), plays an important regulatory role in lipid metabolism and cell function. Recent evi-dence implicated the ERS in both the development of steatosis and progression to nonalcoholic steatohepatitis. In the current review, we discussed the involvement of different fatty a...