摘要：
Nowadays, diabetes and obesity are two main health-threatening metabolic disorders in the world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts its effect by binding with angiotensin II protein J receptor (APJ) and is considered to be linked with diabetes and obesity. Apelin and its receptor are widely present in the body and are involved in many physiological processes, such as glucose and lipid metabolism, homeostasis, endocrine response to stress, and angiogenesis. In this review, we summarize the literatures on the role of the Apelin–APJ system in diabetes and obesity for a better understanding of the mechanism and function of apelin and its receptor in the pathophysiology of diseases that may contribute to the development of new therapies.
摘要：
In this paper, we study the following quasilinear Schrodinger equation -Delta u + V(x)u - Delta(u(2))u = g(x, u), x is an element of R-2, where V(x) and g(x, u) are 1-periodic in x(i)(i = 1, 2). By using a change of variable and a version of Trudinger-Moser inequality, we obtain the existence of nontrivial solutions and infinitely many pairs of geometrically distinct solutions. Our results extend the well-known results in the literature. (C) 2021 Elsevier Ltd. All rights reserved.
摘要：
Coal quality rating can help reduce greenhouse gas emissions, solving the global warming problem. It becomes more important as the carbon neutrality by the mid-21st century agreement is accepted by 195 countries, including China. In this paper, an improved fuzzy comprehensive evaluation method is introduced for coal quality rating. The data used in this work are of the Hostolgoi coalfield of the Xinjiang Province of China. Six industrial analysis indicators are determined as evaluation factors by taking the coal samples of different coal seam depths in the mining area. The super-standard multiple methods and the double-weight super-standard weighting method are combined to form a comprehensive weight. The results show that most of the coal samples of this coal mine are at grades I-II, and the overall coal is with good-quality stability. The evaluation results can improve the coal utilization efficiency and provide scientific guidance for evaluating and exploiting coal resources in coal geological exploration.
摘要：
Proactive low-carbon consumption behaviors (PLCBs) are crucial to achieving carbon neutrality and identifying motivations for PLCBs is indispensable to changing individual consumption patterns. This study establishes a model by incorporating individual-group-level factors with psychological empowerment perception. The ordinary least-squares regression model was applied to identify the influencing factors of PLCBs with data collected from 1732 urban residents in eastern China. Results show that PLCBs are positively influenced by normative internalization, learning capacity, symbol concern, expertise level, and an environmentalism culture. In particular, the effect of learning capacity is the largest, with an influence coefficient of 0.271. A negative impact is observed between the consumerism culture and PLCBs. Moreover, psychological empowerment perception partly medicated the association between individual-group-level factors and PLCBs, and the maximum ratio of mediating effect to the full impact is 62.64%. The study sheds light on low-carbon-related behavioral management, and recommendations to promote PLCBs are further proposed.
摘要：
In this work, the Chebyshev collocation scheme is extended for the Volterra integro-differential equations of pantograph type. First, we construct the operational matrices of pantograph and derivative based on Chebyshev polynomials. Also, the obtained operational matrices are utilized to approximate the derivatives of unknown functions. Furthermore, a detailed analysis of convergence is discussed in the weighted square norm. We conduct some numerical experiments to verify the high performance of the suggested numerical approach. The results show that the computational scheme is accurate.
通讯机构：
[Liang Guo] X;Xilin Gol Institute of Bioengineering, Xilin Gol Food Testing and Risk Assessment Center, Xilingol Vocational College, No.11 Mingantu Road, Inner Mongolia, Xilinhot, China
摘要：
In order to accurately judge the effective bearing area of forgings and detect the inner cavity of hot shaft forgings, a laser based detection method for inner cavity of hot shaft forgings is proposed. According to the characteristics of temperature field around the cavity, the laser technology is introduced to calculate the phase shift between two diffraction beams in any wavelength, normalized sensitivity, subtracted calculation of the two fringe patterns and detection of the size of the cavity. The experimental results show that the residual absolute value of the method is little different from the adaptive threshold, and the cavity location is accurate, which lays a foundation for improving the forging quality and yield.
期刊：
Journal of Organizational and End User Computing,2022年34(3):1-17 ISSN：1546-2234
作者机构：
[Zhao, Yanmei] Northeast Normal Univ, Changchun, Peoples R China.;[Zhao, Yanmei] ChangChun Finance Coll, Sch Econ Management, Changchun, Peoples R China.;[Zhou, Yixin] Shanghai Business Sch, Sch Business Econ, Shanghai, Peoples R China.
关键词：
Big Data;Cloud Platform;Deep Learning;Digital Economy;Scale Measurement Method
摘要：
In recent years, with the acceleration of the process of economic globalization and the deepening of China's financial liberalization, the scale of international short-term capital flows has been extremely rapid. This article mainly studies the deep learning digital economy scale measurement method and its application based on the big data cloud platform. This article uses the indirect method to estimate the stock of renminbi circulating abroad. The results show that the application of big data cloud platforms can increase the development share of digital media and digital transactions in the digital economy and optimize the structure of China's digital economy.
摘要：
Characteristic towns are an essential focus for developing urbanization and implementing rural revitalization in China. Studying the spatial distribution characteristics and influencing factors are of great significance for the scientific and rational cultivation and deployment of characteristic towns and promotion of the integrated development of urban and rural areas. The spatial distribution characteristics and accessibility of 142 characteristic towns in Guangdong Province were investigated using Ripley's K function and kernel density estimation. The results show that (1) the characteristic towns in Guangdong Province present the overall spatial distribution characteristics of “the Pearl River Delta region” and the local distribution characteristics of multicore diffusion in “eastern Guangdong” and “western Guangdong”; (2) the spatial distribution of industrial development, cultural tourism type, innovative and creative characteristic towns shows significant agglomeration, whereas the agglomeration characteristics of agricultural service-oriented and commercial and trade circulation-oriented characteristic towns are not significant; (3) population, economy, resources, and location are the main factors affecting the spatial distribution of characteristic towns in Guangdong Province; (4) the overall spatial accessibility of characteristic towns in Guangdong Province is relatively good. However, the accessibility of characteristic towns of industrial development is better than that of other types of characteristic towns.
期刊：
Mobile Information Systems,2022年2022 ISSN：1574-017X
作者机构：
[Wang, Jing] Anqing Med Coll, Anqing, Peoples R China.;[Zhang, Sihong] Hefei Univ Technol, Hefei, Peoples R China.
摘要：
With the significant increase of studies on cross-cultural learning (CCL) in the recent two decades, it is essential to conduct a systematic review of various literature and their development processes. This article is aimed at revealing research hotspots and emerging trends in CCL studies. This study adapted a visualized bibliometric approach to analyze research articles in the Cross-Cultural Learning-Internet of Things area. We extracted papers published in respected journals as the dataset. Based on bibliometrix, this study collects 1,899 records indexed in the Core Collection of Web of Science (WoS) in the domain of CCL from 2002 to 2021. The findings indicate that the number of published articles shows an apparently upward trend; the United States occupies the leading position, while the most productive journal is <i>Computers & Education</i>; King from Nanyang Technological University of Singapore is the most prolific author, and Nielsen ranks the first in terms of citation; cross-cultural, culture, learning, cross-cultural comparison, and cross-cultural research are found to be the most high-frequency keywords used by authors; cross-cultural projects, students and teachers, cross-cultural research, and educational technologies are the most discussed topics in this field; several notable topics related to CCL and Internet of Things. Visualization study is beneficial to track the hotspots and frontiers of CCL studies in order to effectively grasp the breakthrough points for future research. The results provide helpful information for newcomers, researchers, scholars, and practitioners to identify knowledge gaps, point out future research directions, and move this field forward.
摘要：
Reliable estimation of the atmospheric boundary layer height (ABLH) is critical for a range of meteorological applications, including air quality assessment and weather forecasting. Several algorithms have been proposed to detect ABLH from aerosol LiDAR backscatter data. However, most of these focus on cloud-free conditions or use other ancillary instruments due to strong interference from clouds or residual layer aerosols. In this paper, a machine learning method named the Mahalanobis transform K-near-means (MKnm) algorithm is first proposed to derive ABLH under complex atmospheric conditions using only LiDAR-based instruments. It was applied to the micro pulse LiDAR data obtained at the Southern Great Plains site of the Atmospheric Radiation Measurement (ARM) program. The diurnal cycles of ABLH from cloudy weather were detected by using the gradient method (GM), wavelet covariance transform method (WM), K-means, and MKnm. Meanwhile, the ABLH obtained by these four methods under cloud or residual layer conditions based on micropulse LiDAR data were compared with the reference height retrieved from radiosonde data. The results show that MKnm was good at tracking the diurnal variation of ABLH, and the ABLHs obtained by it have remarkable correlation coefficients and smaller mean absolute error and mean deviation with the radiosonde-derived ABLHs than those measured by other three methods. We conclude that MKnm is a promising algorithm to estimate ABLH under cloud or residual layer conditions.
作者：
Hussain, Naveed;Yau, Stephen S-T*;Zuo, Huaiqing
期刊：
FORUM MATHEMATICUM,2022年34(2):323-345 ISSN：0933-7741
通讯作者：
Yau, Stephen S-T
作者机构：
[Hussain, Naveed] Guangzhou Huashang Coll, Sch Data Sci, Guangzhou 511300, Peoples R China.;[Zuo, Huaiqing; Yau, Stephen S-T] Tsinghua Univ, Dept Math Sci, Beijing 100084, Peoples R China.;[Yau, Stephen S-T] Yanqi Lake Beijing Inst Math Sci & Applicat, Huairou 101400, Peoples R China.
通讯机构：
[Yau, Stephen S-T] T;[Yau, Stephen S-T] Y;Tsinghua Univ, Dept Math Sci, Beijing 100084, Peoples R China.;Yanqi Lake Beijing Inst Math Sci & Applicat, Huairou 101400, Peoples R China.
摘要：
The Levi theorem tells us that every finite-dimensional Lie algebra is the semi-direct product of a semi-simple Lie algebra and a solvable Lie algebra. Brieskorn gave the connection between simple Lie algebras and simple singularities. Simple Lie algebras have been well understood, but not the solvable (nilpotent) Lie algebras. Therefore, it is important to establish connections between singularities and solvable (nilpotent) Lie algebras. In this paper, we give a new connection between nilpotent Lie algebras and nilradicals of derivation Lie algebras of isolated complete intersection singularities. As an application, we obtain the correspondence between the nilpotent Lie algebras of dimension less than or equal to 7 and the nilradicals of derivation Lie algebras of isolated complete intersection singularities with modality less than or equal to 1. Moreover, we give a new characterization theorem for zero-dimensional simple complete intersection singularities.
摘要：
The ability to cope with environmental abiotic stress and biotic stress is crucial for the survival of plants and microorganisms, which enable them to occupy multiple niches in the environment. Previous studies have shown that transcription factors play crucial roles in regulating various biological processes including multiple stress tolerance and response in eukaryotes. This work identified multiple critical transcription factor genes, metabolic pathways and gene ontology (GO) terms related to abiotic stress response were broadly activated by analyzing the transcriptome of phytopathogenic fungus Alternaria alternata under metal ions stresses, oxidative stress, salt stresses, and host-pathogen interaction. We investigated the biological functions and regulatory roles of the bZIP transcriptional factor (TF) genes in the phytopathogenic fungus A.alternata by analyzing targeted gene disrupted mutants. Morphological analysis provides evidence that the bZIP transcription factors (Gcn4, MeaB, Atf1, the ER stress regulator Hac1, and the all development altered-1 gene Ada1) are required for morphogenesis as the colony morphology of these gene deletion mutants was significantly different from that of the wild-type. In addition, bZIPs are involved in the resistance to multiple stresses such as oxidative stress (Ada1, Yap1, MetR) and virulence (Hac1, MetR, Yap1, Ada1) at varying degrees. Transcriptome data demonstrated that the inactivation of bZIPs (Hac1, Atf1, Ada1 and Yap1) significantly affected many genes in multiple critical metabolism pathways and gene ontology (GO) terms. Moreover,the delta Hac1 mutants displayed reduced aerial hypha and are hypersensitivity to endoplasmic reticulum disruptors such as tunicamycin and dithiothreitol. Transcriptome analysis showed that inactivation of Hac1 significantly affected the proteasome process and its downstream unfolded protein binding, indicating that Hac1 participates in the endoplasmic reticulum stress response through the conserved unfolded protein response. Taken together, our findings reveal that bZIP transcription factors function as key regulators of fungal morphogenesis, abiotic stress response and pathogenesis, and expand our understanding of how microbial pathogens utilize these genes to deal with environmental stresses and achieve successful infection in the host plant.
摘要：
Amphotericin B (AMB) is an antifungal drug used for serious fungal infections. However, AMB has adverse reactions such as nephrotoxicity, which limit the clinical application of AMB alone or in combination with other antifungal drugs. Nano or micro drug delivery systems (DDS) have been proven to be effective in reducing the toxic and side effects of drugs. Further, the combination of AMB with other compounds with antifungal activity, such as curcumin (CM), may enhance the synergistic effects. Herein, AMB and CM were co-loaded into porous poly (lactic-co-glycolic acid) (PLGA) microparticles (MPs) to prepare AMB/CM-PLGA MPs. The AMB/CM-PLGA MPs showed a remarkably reduced hemolysis (62.2 ± 0.6%) compared to AMB (80.9 ± 1.1%). The nephrotoxicity of AMB/CM-PLGA MPs is significantly lower than that of AMB. In vitro, AMB/CM-PLGA MPs had better inhibitory effects on the adhesion and biofilm formation of Candida albicans compared with AMB. Experiments on mice infected with C. albicans showed that AMB/CM-PLGA MPs have a better therapeutic effect than AMB in vivo. In summary, AMB/CM-PLGA MPs may be a novel and promising therapeutic candidate for fungal infection.
期刊：
Security and Communication Networks,2022年2022 ISSN：1939-0114
作者机构：
[Tian, Jing] Zhengzhou Tourism Coll, Coll Arts & Culture, Zhengzhou 451464, Peoples R China.;[Yang, Xiaoqiang] Hainan Univ, Sch Mus & Dance, Haikou 570228, Hainan, Peoples R China.
摘要：
Under the synergistic development of social economy and science and technology, the intelligent teaching of dance has become more and more popular. This teaching method can not only decompose dance movements more specifically, which is easy for students to understand and master, but also get rid of the time and space limitation in traditional dance teaching and provide more independent learning opportunities for students. The problem of low accuracy of dance movement recognition due to complex gesture changes in dance movements is addressed. To this end, this paper proposes a modified motion target detection algorithm based on GMM. The dance movement recognition algorithm first extracts the features of dance movements through a feature pyramid network, then uses a multi-feature fusion module to fuse multiple features to improve the algorithm’s estimation of complex postures, and finally completes the recognition of dance movements. Experiments show that our method can maintain a certain recognition rate in the case where the background and target are easily confused, and can effectively improve the dance action recognition accuracy, thus realizing the action correction function for dancers. This also verifies the effectiveness of the action recognition algorithm for dance movement recognition.
摘要：
BACKGROUND: The role of H. pylori infection has been reported in various extragastric diseases, particularly, the correlation between H. pylori and atherosclerosis (AS) have received lots of attention. Some scholars demonstrated that the presence of H. pylori-specific DNA in the sclerotic plaques of atheromatous patients provides biological evidences, with indicating that H. pylori infection is a potential factor of AS. However, the underlying mechanism of H. pylori or their products cross the epithelial barriers to enter the blood circulation remains unclear. Recent studies have shown that the extracellular vesicles (EVs) derived from H. pylori-infected gastric epithelial cells encapsulated H. pylori virulence factor cytotoxin-associated gene A (CagA) and existed in the blood samples of patients or mice, which indicating that they can carry CagA into the blood circulation. Based on these findings, some researchers proposed a hypothesis that H. pylori is involved in the pathogenesis of AS via EVs-based mechanisms. In addition, outer membrane vesicles (OMVs) serve as transport vehicles to deliver H. pylori virulence factors to epithelial cells. It is necessary to discuss the role of H. pylori OMVs in the development of AS. OBJECTIVES: This review will focus on the correlation between H. pylori infection and AS and tried to unveil the possible role of EVs from H. pylori-infected cells and H. pylori OMVs in the pathogenesis of AS, with a view to providing help in refining our knowledge in this aspect. METHODS: All of information included in this review was retrieved from published studies on H. pylori infection in AS. RESULTS: H. pylori infection may be an atherosclerotic risk factor and drives researchers to reevaluate the role of H. pylori in the pathogenesis of AS. Some findings proposed a new hypothesis that H. pylori may be involved in the pathogenesis of AS through EVs-based mechanisms. Besides EVs from H. pylori-infected cells, whether H. pylori OMVs may play some role in the pathogenesis of AS is still remain unclear. CONCLUSION: Existing epidemiological and clinical evidence had shown that there is a possible association between H. pylori and AS. However, except for the larger randomized controlled trials, more basic research about EVs from H. pylori-infected cells and H. pylori OMVs is the need of the hour to unveil the possible role of H. pylori infection in the pathogenesis of AS.
