摘要：
The oral mucosal vaccine has great potential in preventing a series of diseases caused by porcine circovirus type 2 (PCV2) infection. This study constructed a recombinant Bacillus subtilis RB with PCV2 Capsid protein (Cap) on its spore surface and cotB as a fusion partner. The immune properties of the recombinant strain were evaluated in a mouse model. IgA in intestinal contents and IgG in serum were detected by enzyme-linked immunosorbent assay (ELISA). The results demonstrated that recombinant spores could activate strong specific mucosal and humoral immune responses. In addition, spores showed good mucosal immune adjuvant function, promoting the proliferation of CD3+, CD4+ and CD8+ T cells and other immune cells. We also found that the relative expression of inflammatory cytokines such as IL-1 beta, IL-6, IL-10, TNF-alpha and IFN in the small intestinal mucosa was significantly up-regulated under the stimulation of recombinant bacteriophage. These effects are important for the balance of Th1/Th2-like responses. In summary, our results suggest that recombinant B. subtilis RB as a feed additive provides a new strategy for the development of novel and safe PCV2 mucosal subunit vaccines.
摘要：
The piezoelectric (PE) fan is widely adopted in the field of microelectronics cooling due to its advantages of high reliability and good heat dissipation characteristics. However, PE fans driven by conventional circuits suffer from plenty of energy loss. To save energy, we propose an inductor-based charge recovery method and apply it to the driving circuit for the PE fan. Two inductor-based driving circuits, a single inductor-based driving (SID) circuit and a double inductor-based driving (DID) circuit are compared. The SID circuit has a simple structure and a slightly higher energy-saving rate, while the DID circuit introduces no additional oscillations and is more stable. The experimental results show that when the supply voltage changes, both circuits have a relatively stable energy-saving rate, which is about 30% for the SID circuit and 28% for the DID circuit. Moreover, the proposed circuits enjoy the same driving capacity as the conventional circuit, and the driven fan has the same cooling performance.
作者机构：
[Xia, Xing; Luo, Weisheng; Yan, Jiongyi; Li, Fang; Feng, Yinyi; Liang, Jianqin; Feng, Jianfang; Fang, Xuewan; Cui, Xiaojuan] Guangxi Univ Chinese Med, Coll Pharm, Nanning, Peoples R China.;[Yan, Jiongyi] Wuzhou Vocat Coll, Sch Hlth, Wuzhou, Peoples R China.;[Yu, Kai] Guangxi Univ, Coll Anim Sci & Technol, Nanning, Peoples R China.;[Feng, Yinyi] Guangxi Med Univ, Affiliated Hosp 6, Yulin, Peoples R China.;[Liang, Jianqin; Feng, Jianfang] Natl Engn Res Ctr Mfg Technol Tradit Chinese Med, South China Branch, Nanning, Peoples R China.
通讯机构：
[Jianqin Liang; Jianfang Feng; Kai Yu] C;College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China<&wdkj&>College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China<&wdkj&>College of Animal Science and Technology, Guangxi University, Nanning, China
关键词：
9-Cis-retinoic acid;iTRAQ;liver disease;RXRα;traditional Chinese medicine
期刊：
Energy Reports,2022年8(SUPPL-3):207-213 ISSN：2352-4847
通讯作者：
Hu, B.
作者机构：
[Hu, Bing; Guo, Jiajun; Shao, Youyuan] Dongguan Univ Technol, Guangdong Prov Key Lab Distributed Energy Syst, Guangdong Prov Engn Res Ctr Distributed Energy Sy, Dongguan 523808, Peoples R China.;[Yang, Yu] Dongguan City Coll, Dongguan 523419, Peoples R China.
通讯机构：
Guangdong Provincial Key Laboratory of Distributed Energy Systems, Guangdong Provincial Engineering Research Center of Distributed Energy Systems, Dongguan University of Technology, Dongguan, China
会议名称：
8th International Conference on Energy and Environment Research (ICEER) - Developing the World in 2021 with Clean and Safe Energy
会议时间：
SEP 13-17, 2021
会议地点：
Roma, ITALY
会议主办单位：
[Hu, Bing;Guo, Jiajun;Shao, Youyuan] Dongguan Univ Technol, Guangdong Prov Key Lab Distributed Energy Syst, Guangdong Prov Engn Res Ctr Distributed Energy Sy, Dongguan 523808, Peoples R China.^[Yang, Yu] Dongguan City Coll, Dongguan 523419, Peoples R China.
关键词：
Air conditioning;Organic Rankine-vapor compression;Solar
摘要：
This paper takes solar-powered organic Rankine-vapor compression air conditioning as the research object, and uses thermodynamic simulation methods to study the type of working fluid, system design and influencing factors. The results show that the temperature and condensation temperature of the working fluid have an important effect on the performance of the system. The cooling power per unit area collector and the total efficiency of the system first increase and then decrease with the temperature of the working fluid, and decrease with the increase of the condensation temperature. Through performance comparison, it is found that R123 is a more suitable working fluid, the thermodynamic feasibility of a solar-powered organic Rankine-vapor compression air-conditioning system was demonstrated. (C) 2022 The Author(s). Published by Elsevier Ltd.
摘要：
The evaluation of pyrolysis kinetics for waste industrial hemp stem (IHS) is essential to achieve the high-value utilization of agricultural waste. In present study, firstly, non-isothermal pyrolysis experiments of IHS were performed at different heating rates using a thermogravimetric analyzer. Then, the kinetic triplets (apparent activation energy, pre-exponential factor, and reaction mechanism) of the three pseudo components for IHS (hemicellulose, cellulose, and lignin) were determined by a three-parallel-reaction model. Moreover, the pyrolysis products were also characterized via FTIR and SEM. The results showed that the apparent activation energies of hemicellulose, cellulose and lignin were 86.523, 113.257 and 197.961 kJ/mol, respectively; the pre exponential factors were 6.887 x 10(7), 8.179 x 10(9) and 1.801 x 1015 s(-1), respectively; and the reaction mechanism functions were f(alpha) = alpha(1.35629)(1-alpha)(0.34832)[-ln(1-alpha)](- 1.20128), f(alpha) = alpha(3.42900)(1-alpha)(0.01288)[-ln(1-alpha)](-2.84445), f(alpha) = alpha 0.68738(1-alpha)(3.09313)[-ln(1-alpha)](-1.58522), respectively. The release temperature for volatile products of IHS pyrolysis was mainly between 440 and 840 K. IHS as an agricultural waste is a suitable feedstock to produce renewable energy.
期刊：
International Journal of Disaster Risk Reduction,2022年74:102928 ISSN：2212-4209
通讯作者：
Li, Y.
作者机构：
[Wu, Qiong; Li, Dao] Wuhan City Coll, Fac Med, Wuhan, Peoples R China.;[Yan, Min] Hlth Bur Shuanghe City Xinjiang Prov, Shuanghe, Peoples R China.;[Li, Yihua] Yanbian Univ, Coll Med, Dept Prevent Med, Yanji, Peoples R China.
通讯机构：
Department of Epidemiology, Department of Preventive Medicine, Medical College, Yanbian University, 977 Park Road, Jilin Province, Yanji City, China
关键词：
Medical staff;COVID-19;Mental health status;Psychological stress;Normalisation
摘要：
INTRODUCTION: The 2019 coronavirus disease (COVID-19) pandemic has burdened and threatened the psychological health of people around the world, especially those of front-line medical staff. This study aimed to explore the mental-health status and its associated factors amongst the medical workforce of Xinjiang province under the normalisation of the COVID-19 epidemic prevention and control. METHODS: A total of 408 medical staff were recruited from February 20 to March 10, 2021. Symptom Checklist 90 (SCL-90) scale, Social support Scale, and Simplified Coping-Style Questionnaire were applied to assess their mental-health status and stress-coping tendency. Descriptive analyses, welch's T-test, chi-square test, and binary logistic regression were used to analyse the data. RESULTS: The prevalence of mental-health problems was 20.25% (80/395) amongst the surveyed medical staff, and their total symptom mean score (1.31 ± 0.40) was lower than that of the general population (1.44 ± 0.43). Logistic regression analysis revealed that nurse, individual with poor health condition, those who lived with their elderly parents at home, those receiving less social support, and those with a negative stress-coping style were more likely to show psychological problems. CONCLUSION: More attention should be paid to the mental state of the medical workforce during the COVID-19 pandemic. The government and professional institutes should facilitate social supportive activities and essential counselling services to help strengthen the psychological resilience of medical staff. Additionally, it is necessary for health administration committee and hospitals to make COVID-19 prevention practice guides and risk communication principles for improving the mental health of the front-line medical staff.
摘要：
Both moist heatwaves (HWs) and heavy precipitation events (HP) have increased in both frequency and magnitude over China in recent decades. However, the relationship between HW and HP and changes in the lagged coincidence of events (i.e., the occurrence of an HP event several days after an HW event, noted HWHP) remain unknown. We show here that HWHP events account for nearly one-third of HP events over China in summer, with high values in North China, Northeast China, and the East arid zone. HWHP events assessed using the heat index and the wet-bulb temperature methods increased by 45.25 and 23.97% from 1961 to 2019, respectively. These concurrent HWHP events tend to be spatially clustered, and the areas affected simultaneously have grown significantly. The increase in HW is the major driver of these changes in HWHP events, except in the western arid zone and North China. Our findings provide an understanding of the spatiotemporal changes in HWHP events over China and their implications for disaster mitigation.
通讯机构：
[Guang-Hui Dong] G;Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, China
摘要：
Little evidence is available regarding the impact of different sizes of inhaled particulate matter (PM) on inflammatory responses in healthy young adults in connection with toxicological responses. We conducted a five-time repeated measurement panel study on 88 healthy young college students in Guangzhou, China from December 2017 to January 2018. Blood samples were collected from each participant and tested for tumor necrosis factor alpha (TNF-α) levels every week for 5 consecutive weeks. Mass concentrations of ambient PM(2.5), PM(1), PM(0.5) and number concentrations of ambient PM(0.1) were measured. RAW 264.7 macrophages were exposed to PM (PM(10)(-)(2.5), PM(2.5)(-)(1), PM(1)(-)(0.2), PM(0.2)) collected at the same time as the panel study. Cytotoxicity, oxidation and inflammatory parameters, cell cycle and genotoxicity were tested. Particles were characterized for their chemical composition. The trends of associations between PM(2.5), PM(1), PM(0.5) and TNF-α level were consistent in lag 0 and 3 days, and the relative risk decreased as the particle size decreased. All the ambient air pollutants had the similar change trends in lag 1, 4 and 5 days. Similar results in RAW 264.7 macrophages were found; PM(10)(-)(2.5) induced the greatest TNF-α and macrophage inflammatory protein 2 (MIP-2) productions and oxidative damage. PM(1)(-)(0.2) and PM(0.2) induced more significant dose-dependent increases of cell cycle and genotoxic response. In the component concentrations of PM samples, metal elements were PM(10)(-)(2.5) > PM(2.5)(-)(1) > PM(0.2) ≥ PM(1)(-)(0.2); ions and polycyclic aromatic hydrocarbons (PAHs) were PM(0.2) > PM(1)(-)(0.2) > PM(2.5)(-)(1) > PM(10)(-)(2.5). Our results suggested that exposure to all particle sizes was significantly associated with inflammation among healthy young adults and toxicological responses in RAW 264.7 macrophages. Different human and toxicological reactions caused by PM samples indicated the importance of investigating various particle sizes.
作者：
Su, Wanlu;Wang, Jie;Yu, Songyan;Chen, Kang;Gao, Zhengnan;...
期刊：
Journal of Diabetes Investigation,2022年13(7):1222-1234 ISSN：2040-1116
通讯作者：
Mu, YM
作者机构：
[Mu, YM; Mu, Yiming; Su, Wanlu] Nankai Univ, Sch Med, Tianjin, Peoples R China.;[Mu, YM; Mu, Yiming; Chen, Kang; Su, Wanlu] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China.;[Wang, Jie] Capital Med Univ, Beijing Chao Yang Hosp, Dept Endocrinol, Beijing, Peoples R China.;[Yu, Songyan] Capital Med Univ, Beijing Tiantan Hosp, Dept Endocrinol, Beijing, Peoples R China.;[Gao, Zhengnan] Dalian Municipal Cent Hosp, Dept Endocrinol, Dalian, Peoples R China.
通讯机构：
[Mu, YM ] N;Nankai Univ, Sch Med, Tianjin, Peoples R China.;Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China.
关键词：
Metabolic score for insulin resistance;Sex;Urinary albumin-to-creatinine ratio
摘要：
Due to the high specific capacity and energy density, lithium-sulfur batteries have been recognized as the most promising energy storage devices for electric vehicles. However, they are also faced with some problems, such as poor electronic conductivity and severe polysulfide migration. In this work, hierarchical porous carbons (HPCs) are prepared and developed as sulfur host materials in the lithium-sulfur batteries. Due to the hierarchical porous structure, the element sulfur can be uniformly dispersed into the HPCs. Besides, the unique structure also can promote the electron transport and inhibit the polysulfide migration. Based on these advantages, the as-prepared HCPs/S cathode exhibits superior electrochemical performance, including high capacity, excellent rate capability, and stable long-term cycling performance. This work provides a facile way to prepare the sulfur host materials for high-performance lithium-sulfur batteries.
