期刊：
International Journal of Clinical Practice,2022年2022(1):8042915 ISSN：1368-5031
通讯作者：
Hongping Zhang
作者机构：
[Zhang, Hongping; Zhao, Yinshaung] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan 430023, Peoples R China.;[Han, Mo; Wei, Feng] Ctr Dis Prevent & Control Huangpi Dist Wuhan, Wuhan 430300, Peoples R China.;[Chen, Jianquan] Dept Dis Control Hlth & Family Planning Commiss H, Wuhan 430300, Peoples R China.;[Peng, Songxu] Cent South Univ, Xiangya Sch Publ Hlth, Xiangya Sch Med, Dept Maternal & Child Hlth, Changsha 410008, Peoples R China.;[Du, Yukai] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Social Med & Hlth Management, Wuhan 430030, Peoples R China.
通讯机构：
[Hongping Zhang; Mo Han; Yinshaung Zhao; Feng Wei] C;[Yukai Du; Songxu Peng; Jianquan Chen] D;College of Medicine and Health Science,Wuhan Polytechnic University,Wuhan 430023,China<&wdkj&>Department of Disease Control,Health and Family Planning Commission of Huangpi District of Wuhan,Wuhan 430300,China<&wdkj&>Department of Maternal and Child Health,Xiangya School of Public Health,Xiangya School of Medicine,China<&wdkj&>Centers for Disease Prevention & Control of Huangpi District of Wuhan,Wuhan 430300,null,China<&wdkj&>Department of Social Medicine and Health Management,School of Public Health,Tongji Medical College,China
关键词：
aged;Article;chronic disease;cohort analysis;controlled study;cross-sectional study;daily life activity;falling;female;health care cost;health survey;human;lifestyle modification;major clinical study;male;mental health;pilot study;prevalence;risk factor;rural area;daily life activity;dietary fiber;prevalence;prevention and control;risk factor;Accidental Falls;Activities of Daily Living;Aged;Chronic Disease;Cross-Sectional Studies;Dietary Fiber;Female;Humans;Prevalence;Risk Factors
摘要：
<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Background</jats:title>
<jats:p>Social participation (SP) may be an effective measure for decreasing frailty risks. This study investigated whether frequency and type of SP is associated with decreased frailty risk among Chinese middle-aged and older populations.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>Data were derived from the China Health and Retirement Longitudinal Study (CHARLS). Frailty was assessed using the Rockwood’s Cumulative Deficit Frailty Index. SP was measured according to frequency (none, occasional, weekly and daily) and type (interacting with friends [IWF]; playing mah-jong, chess, and cards or visiting community clubs [MCCC], going to community-organized dancing, fitness, qigong and so on [DFQ]; participating in community-related organizations [CRO]; voluntary or charitable work [VOC]; using the Internet [INT]). Smooth curves were used to describe the trend for frailty scores across survey waves. The fixed-effect model (<jats:italic>N</jats:italic> = 9,422) was applied to explore the association between the frequency/type of SP and frailty level. For baseline non-frail respondents (<jats:italic>N</jats:italic> = 6,073), the time-varying Cox regression model was used to calculate relative risk of frailty in different SP groups.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>Weekly (β = − 0.006; 95%CI: [− 0.009, − 0.003]) and daily (β = − 0.009; 95% CI: [− 0.012, − 0.007]) SP is associated with lower frailty scores using the fixed-effect models. Time-varying Cox regressions present lower risks of frailty in daily SP group (HR = 0.76; 95% CI: [0.69, 0.84]). SP types that can significantly decrease frailty risk include IWF, MCCC and DFQ. Daily IWF and daily DFQ decreases frailty risk in those aged < 65years, female and urban respondents, but not in those aged ≥ 65years, male and rural respondents. The impact of daily MCCC is significant in all subgroups, whereas that of lower-frequent MCCC is not significant in those aged ≥ 65years, male and rural respondents.</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>This study demonstrated that enhancing participation in social activities could decrease frailty risk among middle-aged and older populations, especially communicative activities, intellectually demanding/engaging activities and community-organized physical activities. The results suggested very accurate, operable, and valuable intervening measures for promoting healthy ageing.</jats:p>
</jats:sec>
作者机构：
[Li, Shang-Ze; Huang, Xi-Cheng; Zhang, Xiao-Dong; Li, Chao; Du, Run-Lei; Chen, Jie] Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072, Hubei, Peoples R China.;[Li, Shang-Ze; Song, Xue-Min] Wuhan Univ, Res Ctr Anesthesiol & Crit Care Med, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.;[Liu, Wenbin] Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan 430023, Hubei, Peoples R China.
通讯机构：
[Xue-Min Song] R;[Run-Lei Du] H;Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei Province, 430072, PR China<&wdkj&>Research Centre of Anesthesiology and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, 430071, PR China
摘要：
Protein tyrosine phosphatase non-receptor type 18 (PTPN18) is often highly expressed in colorectal cancer (CRC), but its role in this disease remains unclear. We demonstrated that PTPN18 overexpression promotes growth and tumorigenesis in CRC cells and that PTPN18 deficiency yields the opposite results in vitro. Moreover, a xenograft assay showed that PTPN18 deficiency significantly inhibited tumorigenesis in vivo. PTPN18 activated the MYC signaling pathway and enhanced CDK4 expression, which is tightly associated with the cell cycle and proliferation in cancer cells. Finally, we found that MYC interacted with PTPN18 and increased the protein level of MYC. In conclusion, our results suggest that PTPN18 promotes CRC development by stabilizing the MYC protein level, which in turn activates the MYC-CDK4 axis. Thus, PTPN18 could be a novel therapeutic target in the future. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V.
作者：
Wang, Xuan*;Zhang, Hongling;Cheng, Qingzhou;Chen, Jing;Qiu, Nan
期刊：
PROCEEDINGS OF THE 6TH INTERNATIONAL CONFERENCE ON ELECTRONIC, MECHANICAL, INFORMATION AND MANAGEMENT SOCIETY (EMIM),2016年40:1041-1045 ISSN：2352-538X
摘要：
Nowadays, an effective teaching platform is an important factor in the distance education. In the paper, the structure and functional modules of the teaching platform system based on web technology is studied comprehensively, and these functional modules of the teaching platform is introduced in detail. And the implementation process of the main technical and design principles is generated in the paper. The platform has some function of management and teaching in the education based on multi-layer structure.
