摘要：
The purpose is to apply the fractal statistical model to analyze tourist flow feature of scenic area, and promote the effective performance of scenic area. Zhangjiajie scenic area is taken as an example. First, its natural resources characteristics, ecological environment and problems in the development of scenic area are analyzed in detail; moreover, fractal theory and fractal dimension calculation method are elaborated; finally, wavelet transform is proposed to analyze the nonlinear transformation characteristics of tourist flow. The results show that the changes of the high-frequency layer H-1, H-2, H-3 and H-4 all have cyclical fluctuations in the change of tourist flow. The change range of tourist flow in spring and autumn is relatively large, and the tourist flow in winter is low. Inbound tourism tourist flow has a certain seasonal regularity, with obvious characteristics of low and peak seasons. Wulingyuan scenic spot and Tianmen Mountain scenic spot of Zhangjiajie have three non-scale ranges, which are related to the scale and change of tourist flow. The concentration of inbound tourist flow in the peak season still exists in both scenic spots, and it is more and more serious. Tourist flow of inbound tourists from April to May and from September to October is large, accounting for more than half of the annual tourist flow, while most of the other periods are in the off-season.
作者机构：
[He, Jie; Yu, Mi; Li, Xiaoyan] Chengdu Med Coll, Clin Med Coll, Chengdu, Peoples R China.;[He, Jie; Yu, Mi] Chengdu Med Coll, Dept Pulm & Crit Care Med, Affiliated Hosp 1, Chengdu, Peoples R China.;[Li, Xiaoyan] Chengdu Med Coll, Dept Endocrinol, Affiliated Hosp 1, Chengdu, Peoples R China.
通讯机构：
[He, Jie] C;Chengdu Med Coll, Clin Med Coll, Chengdu, Peoples R China.;Chengdu Med Coll, Dept Pulm & Crit Care Med, Affiliated Hosp 1, Chengdu, Peoples R China.
摘要：
Objective: Ferroptosis has an important role in developing pulmonary fibrosis. The present project aimed to identify and validate the potential ferroptosis-related genes in pulmonary fibrosis by bioinformatics analyses and experiments.Methods: First, the pulmonary fibrosis tissue sequencing data were obtained from Gene Expression Omnibus (GEO) and FerrDb databases. Bioinformatics methods were used to analyze the differentially expressed genes (DEGs) between the normal control group and the pulmonary fibrosis group and extract ferroptosis-related DEGs. Hub genes were screened by enrichment analysis, protein-protein interaction (PPI) analysis, and random forest algorithm. Finally, mouse pulmonary fibrosis model was made for performing an exercise intervention and the hub genes' expression was verified through qRT-PCR.Results: 13 up-regulated genes and 7 down-regulated genes were identified as ferroptosis-related DEGs by comparing 103 lung tissues with idiopathic pulmonary fibrosis (IPF) and 103 normal lung tissues. PPI results indicated the interactions among these ferroptosis-related genes. Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway enrichment and Genome-Ontology (GO) enrichment analyses showed that these ferroptosis-related genes involved in the organic anion transport, response to hypoxia, response to decrease oxygen level, HIF-1 signaling pathway, renal cell carcinoma, and arachidonic acid metabolism signaling pathway. The confirmed genes using PPI analysis and random forest algorithm included CAV1, NOS2, GDF15, HNF4A, and CDKN2A. qRT-PCR of the fibrotic lung tissues from the mouse model showed that the mRNA levels of NOS2 and GDF15 were up-regulated, while CAV1 and CDKN2A were down-regulated. Also, treadmill training led to an increased expression of CAV1 and CDKN2A and a decrease in the expression of NOS2 and GDF15.Conclusion: Using bioinformatics analysis, 20 potential genes were identified to be associated with ferroptosis in pulmonary fibrosis. CAV1, NOS2, GDF15, and CDKN2A were demonstrated to be influencing the development of pulmonary fibrosis by regulating ferroptosis. These findings suggested that, as an aerobic exercise treatment, treadmill training reduced ferroptosis in the pulmonary fibrosis tissues, and thus, reduces inflammation in the lungs. Aerobic exercise training initiate concomitantly with induction of pulmonary fibrosis reduces ferroptosis in lung. These results may develop our knowledge about pulmonary fibrosis and may contribute to its treatment.
摘要：
Aging is a key risk factor for angiogenic dysfunction and cardiovascular diseases, including heart failure, hypertension, atherosclerosis, diabetes, and stroke. Members of the NAD+-dependent class III histone deacetylase family, sirtuins, are conserved regulators of aging and cardiovascular and cerebrovascular diseases. The sirtuin SIRT6 is predominantly located in the nucleus and shows deacetylase activity for acetylated histone 3 lysine 56 and lysine 9 as well as for some non-histone proteins. Over the past decade, experimental analyses in rodents and non-human primates have demonstrated the critical role of SIRT6 in extending lifespan. Recent studies highlighted the pleiotropic protective actions of SIRT6 in angiogenesis and cardiovascular diseases, including atherosclerosis, hypertension, heart failure, and stroke. Mechanistically, SIRT6 participates in vascular diseases via epigenetic regulation of endothelial cells, vascular smooth muscle cells, and immune cells. Importantly, SIRT6 activators (e.g., MDL-800/MDL-811) have provided therapeutic value for treating age related vascular disorders. Here, we summarized the roles of sirtuins in cardiovascular diseases; reviewed recent advances in the understanding of SIRT6 in vascular biology, cardiovascular aging, and diseases; highlighted its therapeutic potential; and discussed future perspectives.
作者机构：
[Li, Sheyu; Shen, Yanjiao] Sichuan Univ, Dept Guideline & Rapid Recommendat, Cochrane China Ctr, West China Hosp,Chinese Evidence Based Med Ctr,MA, Chengdu, Peoples R China.;[Li, Sheyu; Liu, Dan] Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, Chengdu, Peoples R China.;[He, Yazhou] Sichuan Univ, West China Sch Publ Hlth, Dept Oncol, Chengdu, Peoples R China.;[He, Yazhou] Sichuan Univ, West China Fourth Hosp, Dept Oncol, Chengdu, Peoples R China.;[Tan, Fucha] Heze Med Coll, Dept Geriatr, Affiliated Hosp, Heze, Peoples R China.
摘要：
Background: Many clinical practice guidelines strongly recommend exercise as an intervention for patients with sarcopenia. However, the significance of exercise on patient-important outcomes in older adults with sarcopenia is inconsistent when considering available minimal important differences. To synthesize current systematic review and meta-analyses evidence on the efficacy of exercise on patient-important outcomes in the treatment of sarcopenia in older adults.Methods: We searched MEDLINE, EMBASE, Cochrane Library (Cochrane database of systematic review, CDSR) via OvidSP and Web of science until April 2021 and reference lists. Two independent investigators performed abstracted and title screening, assessed the full text and quality of evidence. This umbrella review included systematic reviews and meta-analyses of randomized controlled trials (RCTs). Eligible reviews aim to evaluate the effect of exercise on patient-important sarcopenic outcomes (muscle or physical function, mortality, and quality of life) in treating sarcopenia in older people. We used the minimally important differences (MIDs) of these outcomes to assess if the effects of exercise matter to patients.Results: This umbrella review provided a broad overview of the existing evidence and evaluated the systematic reviews' methodological quality and evidence for all these associations. In older patients with sarcopenia, moderate- to high-quality evidence showed that exercise intervention probably increases walking speed and improved physical performance (measured by TUG test); exercise may increase the muscle strength (grip strength, keen extension strength); but the effect size for grip strength probably too small to achieve patients important changes. Evidence for older people with sarcopenic obesity is limited, and we found the consistent effect of exercise interventions on grip strength and usual walking speed.Conclusion: Exercise has a positive and important effect on physical performance for older adults with sarcopenia, which supports leaving the current recommendations unchanged. New systematic reviews to summarize the effect of exercise on the quality of life are warranted to fill the current evidence gap.
摘要：
The migration of the discharge products of polysulfide in the lithium-sulfur batteries inhibits their practical application. In addition, the poor electron transport also limits the specific capacity of the element sulfur. Therefore, these two problems must be solved to achieve the high electrochemical performance of the lithium-sulfur batteries. Herein, we prepared NiCo2O4 materials via a facile method and designed it as the sulfur host materials in the lithium-sulfur batteries. The as-prepared NiCo2O4/S (NCO/S) composites showed excellent ability to stabilize the discharge products of the soluble polysulfide. Also, the NCO/S composites exhibit high electronic conductivity compared to the pure S cathode. As a result, the as-prepared NCO/S composites display high specific capacity and superior cycling stability.
摘要：
This single-arm, multicentre, phase I study is the first study of zanubrutinib, a potent, specific, irreversible Bruton tyrosine kinase (BTK) inhibitor, in Chinese patients with relapsed/refractory B-cell malignancies. The objectives were to evaluate safety and preliminary anti-tumour activity. Forty-four patients received zanubrutinib 320 mg once daily (QD) (n = 10) or 160 mg twice daily (BID) (n = 34) until disease progression or unacceptable toxicity. 29.5% of patients received zanubrutinib for at least two years. The most common adverse event (AE) and the most common grade 3 or higher AE was neutrophil count decreased (54.5% and 25.0% respectively). Two patients (4.5%) discontinued treatment due to AEs and one treatment-emergent AE led to death. All haemorrhagic events were grade 1-2 (except for one non-serious grade 3 purpura). No second primary malignancies, tumour lysis syndrome, or atrial fibrillation/flutter occurred. The overall response rate was 52.3% (complete response rate, 18.2%). Patients with all cancer subtypes benefited from treatment. BTK C481S/R or L528W mutations were found in zanubrutinib-progressive patients. The safety/efficacy profiles of patients treated with 320 mg QD and 160 mg BID were comparable and similar daily area under the curve (AUC) was achieved. Overall, zanubrutinib was well tolerated and either of these two regimens is clinically practical. Registered at ClinicalTrials.gov (NCT03189524, on 16 June 2017, https://clinicaltrials.gov/ct2/show/NCT03189524).
摘要：
The study was designed to explore a clinical manifestation-based quantitative scoring model to assist the differentiation between psychogenic pseudosyncope (PPS) and vasovagal syncope (VVS) in children. In this retrospective case-control study, the training set included 233 pediatric patients aged 5-17 years (183 children with VVS and 50 with PPS) and the validation set consisted of another 138 patients aged 5-15 years (100 children with VVS and 38 with PPS). In the training set study, the demographic characteristics and clinical presentation of patients were compared between PPS and VVS. The independent variables were analyzed by binary logistic regression, and the score for each variable was given according to the approximate values of odds ratio (OR) to develop a scoring model for distinguishing PPS and VVS. The cut-off scores and area under the curve (AUC) for differentiating PPS and VVS cases were calculated using receiver operating characteristic (ROC) curve. Then, the ability of the scoring model to differentiate PPS from VVS was validated by the true clinical diagnosis of PPS and VVS in the validation set. In the training set, there were 7 variables with significant differences between the PPS and VVS groups, including duration of loss of consciousness (DLOC) (p < 0.01), daily frequency of attacks (p < 0.01), BMI (p < 0.01), 24-h average HR (p < 0.01), upright posture (p < 0.01), family history of syncope (p < 0.05) and precursors (p < 0.01). The binary regression analysis showed that upright posture, DLOC, daily frequency of attacks, and BMI were independent variables to distinguish between PPS and VVS. Based on the OR values of each independent variable, a score of 5 as the cut-off point for differentiating PPS from VVS yielded the sensitivity and specificity of 92.0% and 90.7%, respectively, and the AUC value was 0.965 (95% confidence interval: 0.945-0.986, p < 0.01). The sensitivity, specificity, and accuracy of this scoring model in the external validation set to distinguish PPS from VVS were 73.7%, 93.0%, and 87.7%, respectively. Therefore, the clinical manifestation-based scoring model is a simple and efficient measure to distinguish between PPS and VVS.
摘要：
Non-destructive stress measurement is necessary to provide safety maintenance in some extreme machining environments. This paper reports a case study that reveals the potential application of automatic metal stress monitoring with the aid of the magnetic Barkhausen noise (MBN) signal and deep learning algorithms (convolutional neural network, CNN, and long short-term memory, LSTM). Specifically, we applied the experimental magnetic signals from steel samples to validate the feasibility and efficiency of two deep learning models for stress prediction. The results indicate that the CNN model possesses a faster training speed and a better test accuracy (91.4 %), which confirms the feasibility of automatic stress monitoring applications.
摘要：
Two tetraphenylethylene-based fluorescent conjugated microporous polymers (TTTPT and TTDAT) were obtained by the Friedel-Crafts polymerization reactions catalysed by CH3SO3H. In virtue of containing tetraphenylethylene, triphenylamine and s-triazine units in their porous skeletons, the resulting TTTPT and TTDAT show excellent fluorescence sensing performance for trinitrophenol (TNP) with high quenching coefficients of 1.66 x 10(4) and 1.31 x 10(5) l mol(-1), respectively. TTDAT can also sense to dinitrophenol (DNP) with the K-sv of 2.70 x 10(4) l mol(-1). The fluorescent quenching mechanisms of TTTPT and TTDAT for selective detecting TNP attribute to conventional photoinduced electron-transfer mechanism, absorption competition quenching mechanism and/or the resonant energy transfer mechanism.
摘要：
To evaluate the application effect of antimicrobial peptides Gal-13 (AMP Gal-13) instead of antibiotic feed additives, 90 7-day-old Ross 308 broilers were randomly divided into 3 groups. Group A was fed a basic diet as the control, and Groups B and C were supplemented with AMP Gal-13 (100 mg/kg and 200 mg/kg, respectively). After a 35-day feeding experiment, the weight and average daily gain (ADG) of the broilers in Group B were significantly higher than those of the broilers in Group A. The Enterococcus sp. and Escherichia coli counts in the ileum and cecum in Group A were significantly higher than those in Groups B and C, while the Lactic acid bacteria (LAB) and Bifidobacterium sp. counts were significantly lower. The amylase activity of the jejunum in Group B was significantly higher than that in Group A. The villus length (VL): crypt depth (CD) ratios of the jejunum and ileum in Group B were significantly higher than those in Group A. The glutathione peroxidase (GSH-Px) activities in the liver and serum in Groups B and C were significantly higher than those in Group A, while the malondialdehyde (MDA) activity was significantly lower. The titers of Newcastle disease virus (NDV)-specific antibodies were elevated significantly in Group B at the age of 42 days. Additionally, the weights of the spleen and thymus were significantly increased. The expression levels of Il-2, Il-6, Tgf-β4, Tnf-α, and Mif in the spleen in Groups B and C were significantly downregulated to different degrees; Il-4 expression in Group B was significantly upregulated, while Ifn-γ expression in Group C was significantly upregulated. The results suggested that adding AMP Gal-13 to the diet could improve intestinal digestion, the antioxidant capacity, and immune function, ultimately promoting the growth of broilers.
摘要：
In this paper, we consider coupled plate equations with indirect damping including friction and structural damping. By using suitable diagonalization procedure associated with WKB analysis, we derive asymptotic behavior of solutions in the Fourier space. Then, smoothing effect and decay properties in the
$$L^p-L^q$$
framework of solutions are derived by employing Fourier analysis and representation of solution. We investigate several thresholds to describe smoothing effect and different types of decay properties, for example, Gevrey smoothing and regularity-loss. Finally, we derive approximation of solutions by finding the gained decay rate.
摘要：
As possible alternatives to lithium-ion batteries, potassium-ion batteries (KIBs) are attractive due to the abundant resource of potassium and their rational capability. However, to achieve fast discharge/charge ability and long-cycle life for carbon-based anodes remain one of the challenging issues for KIB appli-cation. Herein, porous-structured and N-doping carbon nanofibers (P-NCNFs) with surface defects were reasonably prepared via a facile electrospinning method. In such architecture, the N-doping can enhance electronic conductivity and reactivity by introducing additional defects, and the porous structure can boost the infiltration of electrolyte in electrode, alleviating the concentration polarization and finally en-hancing the KIB performance. Used as anodes, P-NCNFs-c delivered excellent KIB performance with a high reversible capacity of 165 mAh g(-1) cycling after 20 0 0 cycles at 1.0 A g(-1), and good rate stability with a capacity retention of over 242 mAh g(-1) for 600 cycles, being much better than pure CNFs with-out N-doping and pore-forming treatment. In addition, kinetic analysis revealed that the enhanced KIB performance of P-NCNFs-c could be also associated with the contribution of capacitive charge. Thus, this synthetic strategy provided a promising anode material for next-generation KIBs.& nbsp;(c) 2021 Elsevier Ltd. All rights reserved.
关键词：
Chinese users;digit-only passwords;financial account passwords;format-preserving encryption;ID card
摘要：
Abstract Password‐based authentication is widely used in website access. Current studies on password security have focused considerable attention on letter‐only passwords or passwords that include both letters and digits. However, little research has been conducted on commercial and digit‐only passwords. In this paper, we comprehensively evaluate digit‐only passwords by analyzing approximately 130,000 passwords from the 12306 data set. We observe that approximately 20% of six‐digit passwords belonging to Chinese users include the user's identity document (ID) card information. Most of the passwords are found to be related to the user's birth dates. Additionally, we demonstrate that male users are more likely to set passwords with digits extracted from their ID card numbers than female users. It is the first time that the relation between real‐user passwords and ID card series numbers was considered. It focuses on actual attack methodologies and real‐user passwords, which renders this study an explicit study on digit‐only password security. We propose a password‐encryption authentication model based on FF3‐1 to implement secure storage of passwords. We experiment with ciphertext and plaintext passwords using three–three and four–two structures combined with probabilistic context‐free grammars. The cracking success rates of ciphertext passwords are found to be 0.086% and 1.06%, and they can recover 59.83% and 33.2% of the passwords in the test set. Conversely, using plaintext passwords results in the recovery of 98% and 85% of passwords in the test set. Our results demonstrate that the use of encryption for password storage can significantly reduce the cracking success rate of attackers.
摘要：
The second-order ordinary differential equation (ODE) often emerges from applied science, such as orbital mechanics, quantum mechanics, physical chemistry, electronics. As we all know, Runge-Kutta-Nystrom (RKN) method is indispensable when solving the second-order ODE. In addition, there are also some intrinsic properties in these fields. How to preserve these properties must be considered when seeking the numerical solutions. Thus, in this paper, we focus on the construction of the implicit RKN method. Combining the symmetry conditions and symplecticness conditions, sixth-order implicit exponentially fitted/trigonometrically fitted RKN integrators are obtained. The designed methods have the power of solving Hamiltonian system. And we make some numerical experiments to show the efficiency and competence of the new methods compared with some highly efficient implicit codes in the literature.
摘要：
In recent years, the civil coal combustion has caused serious non-point source air pollution. In order to improve the air pollution caused by the burning of civilian coal and enhance the combustion performance and energy efficiency of anthracite, four kinds of RH-AT molding particles with different mixing ratios were prepared by hot pressing method with rice husk biomass anthracite as raw material, and the influence of the mixing ratio of rice husk biomass and anthracite on the molding performance, combustion performance and NOx emission performance of RH-AT shaped particles was studied. The test results show that the addition of an appropriate amount of RH can promote the molding performance of RH-AT particles. At a molding temperature of 100 C, the lignin of RH starts to soften and has a certain viscosity. Without additional additives, it can act as a binder, promote the bonding between particles and improve their compressive strength. At the same time, it can also reduce the resistance in the compression process and reduce the specific energy consumption of molding. The mixing of RH can increase the heating efficiency of AT in the low temperature stage and improve the combustion performance of the shaped particles. Both the comprehensive combustion characteristic index and the maximum combustion rate gradually increase with the increase of the RH addition ratio, and the improvement efficiency reaches 227.9% and 72.2?/0, respectively. When the addition ratio of RH is increased from 20% to 80?/0, the total amount of NOx released by the shaped particles is reduced by 0.11mg, 0.27mg, 0.35mg and 0.66mg respectively, and the maximum reduction ratio is 75.86%.
期刊：
AStA Advances in Statistical Analysis,2022年106(1):79-96 ISSN：1863-8171
通讯作者：
Bingzhen Chen
作者机构：
[Chen, Bingzhen] Renmin Univ China, Inst Stat & Big Data, 59 Zhongguancun Ave, Beijing 100872, Peoples R China.;[Zhai, Wenjuan] Cangzhou Jiaotong Coll, Dept Appl Math, Cangzhou 061100, Peoples R China.;[Kong, Lingchen] Beijing Jiaotong Univ, Dept Appl Math, Beijing 100044, Peoples R China.
通讯机构：
[Bingzhen Chen] I;Institute of Statistics and Big Data, Renmin University of China, Beijing, China
关键词：
Robust estimator;Multivariate linear regression;Collinearity;Row-sparsity;Sub-gradient algorithm
摘要：
Multivariate data is collected in many fields, such as chemometrics, econometrics, financial engineering and genetics. In multivariate data, heteroscedasticity and collinearity occur frequently. And selecting material predictors is also a key issue when analyzing multivariate data. To accomplish these tasks, multivariate linear regression model is often constructed. We thus propose row-sparse elastic-net regularized multivariate Huber regression model in this paper. For this new model, we proof its grouping effect property and the property of resisting sample outliers. Based on the KKT condition, an accelerated proximal sub-gradient algorithm is designed to solve the proposed model and its convergency is also established. To demonstrate the accuracy and efficiency, simulation and real data experiments are carried out. The numerical results show that the new model can deal with heteroscedasticity and collinearity well.
作者机构：
[Dai, Lili; Lu, He] Lianyungang Normal Coll, Inst Smart Mat & Appl Technol, Lianyungang 222006, Peoples R China.;[Hua, Dezheng; Chen, Hongming; Lu, He; Liu, Xinhua] China Univ Min & Technol, Sch Mechatron Engn, Xuzhou 211006, Jiangsu, Peoples R China.;[Glowacz, Adam] AGH Univ Sci & Technol, Dept Automat Control & Robot, PL-30059 Krakow, Poland.;[Krolczyk, Grzegorz; Li, Zhixiong] Opole Univ Technol, Fac Mech Engn, PL-45758 Opole, Poland.;[Li, Zhixiong] Yonsei Univ, Yonsei Frontier Lab, Seoul 03722, South Korea.
关键词：
production scheduling;hybrid genetic algorithm;artificial intelligence;sustainable design;discrete manufacturing
摘要：
Due to the complexity of the production shop in discrete manufacturing industry, the traditional genetic algorithm (GA) cannot solve the production scheduling problem well. In order to enhance the GA-based method to solve the production scheduling problem effectively, the simulated annealing algorithm (SAA) is used to develop an improved hybrid genetic algorithm. Firstly, the crossover probability and mutation probability of the genetic operation are adjusted, and the elite replacement operation is adopted for simulated annealing operator. Then, a mutation method is used for the comparison and replacement of the genetic operations to obtain the optimal value of the current state. Lastly, the proposed hybrid genetic algorithm is compared with several scheduling algorithms, and the superiority and efficiency of the proposed method are verified in solving the production scheduling.
