摘要：
Alzheimer's disease (AD) is one of the most debilitating neurodegenerative nerve diseases, seriously affecting one's ability to carry out daily activities. AD is both progressive and incurable, but molecular studies have begun to shed light on the mechanisms that underlie it. Immunochemical staining showed that cell bodies of Purkinje cells in the cerebellum were significantly reduced in AD rats compared with normal rats. Heat shock protein 70 (HSP70) was found to prevent polyglutamine aggregation in Huntington's disease and spinocerebellar ataxias (SCAs) and to relieve symptoms in SCAs and Parkinson's disease. Recently, AD-related phenotypes were found to be suppressed in HSP70 transgenic rats. However, the effects of other HSPs and the mechanisms of HSP-triggered changes in AD are unknown. In this study, we found that expression levels of HSP60, -70, and -90 were downregulated in the cerebella of rats with AD. Furthermore, heat shock factor 1 (HSF1), a key transcription factor for the expression of HSP genes, was found to be greatly decreased in the cerebella of AD rats. Even more interesting, injection of lentivirus vector-HSF1 into the cerebella of AD rats significantly increased HSF1 and HSP expression levels and induced an increase in the number of Purkinje cell bodies. Our findings provide novel evidence that low expression of HSPs in AD rats is dependent on the low expression of HSF1, and increased expression of HSF1 contributes to the reversal of cerebellar Purkinje cell deficiency in AD. Therefore, increasing HSF1 expression is a potential new strategy for the treatment of AD.
摘要：
In this paper, a versatile complementary metal oxide semiconductor (CMOS) readout integrated circuit (ROIC) for microbolometric infrared focal plane array (IRFPA) is presented. By applying a variable column-shared current mirror (CM) proportional circuit, the ROIC can be used in applications on different occasions from very high background to quite low background. With column-shared blind bolometer, CM proportional circuit and capacitor feedback trans-impedance amplifier (CTIA) integration circuit, the ROIC has high performance such as high gain, low noise, low power dissipation and large output dynamic range while maintaining simple structure. Moreover, a common high correlated double sampling (CDS) circuit is utilized to improve noise performance of the ROIC under low power dissipation. An experimentally prototypical readout chip is designed and fabricated for microbolometric IRFPAs to verify the performance of the ROIC. Theoretical analysis and experimentally measuring results indicate that the proposed CMOS ROIC can be applied to microbolometric IRFPAs. Crown Copyright (C) 2013 Published by Elsevier GmbH. All rights reserved.
作者机构：
School of Electrical & Electronic Engineering,Wuhan Polytechnic University,Wuhan 430023,China;Wuhan National Laboratory for Optoelectronics,Wuhan 430074,China
会议名称：
Asia Communications and Photonics Conference (ACP2013)& International Conferene on Information Photonics and Optical Communications(2013亚洲光纤通信与光电国际会议暨亚太光通信国际会议
会议时间：
2013-11-12
会议地点：
北京
会议论文集名称：
Asia Communications and Photonics Conference (ACP2013)& International Conferene on Information Photonics and Optical Communications(2013亚洲光纤通信与光电国际会议暨亚太光通信国际会议论文集
摘要：
By using surface micromachining technique,an optical switch based on nanocrystalline VO2 film with low phase transition temperature is designed and fabricated.Measured results show that the optical switch can realize its switching function.
摘要：
The analysis of the (7, 4) binary hamming coding and decoding algorithm in wireless communications with C language programming was given and the verification testing was implemented on a HD 111 communication principle platform. The theory result was in consistent with that of the experiment. It shows that (7, 4) binary hamming coding could rectify one error symbol which would emerge in the signal transmission process and the decoding is easily to be brought about.
摘要：
The article first analyses the rise of green supply chain background,Chinese enterprises implement green supply chain management significance and necessity,and the consolidated results of previous stu
