Stereochemical determination of four 10-membered ring resorcylic acid lactones from the desert plant endophytic fungus Chaetosphaeronema hispidulum
作者：
Zheng, Min;Xu, Zhen-Lu;Yang, Run-Mei;Hu, Shen-Cai* ;Ding, Gang* ;...
期刊：
JOURNAL OF ANTIBIOTICS ,2020年73(7):471-474 ISSN：0021-8820
通讯作者：
Hu, Shen-Cai;Ding, Gang;Zhang, Yong-Gang
作者机构：
[Hu, Shen-Cai; Zheng, Min] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.;[Ding, Gang; Yang, Run-Mei; Zheng, Min; Xu, Zhen-Lu] Chinese Acad Med Sci & Peking Union Med Coll, Key Lab Bioact Subst & Resources Utilizat Chinese, Inst Med Plant Dev, Minist Educ, Beijing 100193, Peoples R China.;[Zhang, Yong-Gang; Xu, Zhen-Lu] Qilu Univ Technol, Shandong Acad Sci, Inst Biol, Jinan 250103, Shandong, Peoples R China.;[Zhang, Yong-Gang; Xu, Zhen-Lu] Shandong Normal Univ, Coll Life Sci, Jinan 250014, Shandong, Peoples R China.;[Qin, Jian-Chun] Jilin Univ, Coll Plant Sci, Changchun 130062, Jilin, Peoples R China.
通讯机构：
[Hu, Shen-Cai] W;[Ding, Gang] C;[Zhang, Yong-Gang] Q;[Zhang, Yong-Gang] S;Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.
关键词：
cytotoxic agent;hispidulactone b;hispidulactone f;lactone derivative;sonnerlactone;unclassified drug;antineoplastic agent;lactone;Article;biosynthesis;carbon nuclear magnetic resonance;cell proliferation;Chaetosphaeronema hispidulum;cytotoxicity;drug determination;electrospray mass spectrometry;endophytic fungus;Hep-G2 cell line;heteronuclear multiple bond correlation;heteronuclear single quantum coherence;high performance liquid chromatography;human;human cell;nonhuman;priority journal;proton nuclear magnetic resonance;stereochemistry;stereoisomerism;X ray diffraction;Ascomycetes;chemistry;endophyte;microbiology;nuclear magnetic resonance spectroscopy;plant;procedures;tumor cell line;Antineoplastic Agents;Ascomycota;Cell Line, Tumor;Endophytes;Hep G2 Cells;Humans;Lactones;Magnetic Resonance Spectroscopy;Plants;Stereoisomerism
摘要：
Four 10-membered ring resorcylic acid lactones (RALs) including a new compound hispidulactone F (1) and three known analogs hispidulactone B (2), 2 R, 4R-sonnerlactone (3), and 2 R, 4S-sonnerlactone (4) were isolated from the special bioenvironmental desert plant endophytic fungus Chaetosphaeronema hispidulum. The structure of the new compound hispidulactone F (1) was determined by extensive spectra analysis including HR-ESI-MS, NMR (1H, 13C, 1H-1H COSY, HSQC, and HMBC). Hispidulactone F (1) and hispidulactone B (2) were a pair of stereoisomers at C-3, whereas 2 R, 4R-sonnerlactone (3) and 2 R, 4S-sonnerlactone (4) were another pair of stereoisomers at C-4. The stereochemistries of the hydroxyl groups at C-3 in 1 and 2, and at C-4 in 3 and 4 were first determined by modified Mosher’s reactions. Thus, the absolute configuration C-3 in hispidulactone B (2) was not right in our previous report, and was rectified to be R. Compounds 1 and 4 were evaluated for their cytotoxic effects on the proliferation of HepG2. The possible biosynthetic pathway of compounds 1–4 was also presented. © 2020, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.
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英文
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A Choline-Recognizing Monomeric Lysin, ClyJ-3m, Shows Elevated Activity against Streptococcus pneumoniae
作者：
Luo, Dehua;Huang, Li;Gondil, Vijay Singh;Zhou, Wanli;Yang, Wan;...
期刊：
Antimicrobial Agents and Chemotherapy ,2020年64(12) ISSN：0066-4804
通讯作者：
Yang, Hang;Wei, Hongping
作者机构：
[Yang, Wan; Luo, Dehua; He, Jin; Jia, Minghui] Huazhong Agr Univ, Coll Life Sci & Technol, State Key Lab Agr Microbiol, Wuhan, Peoples R China.;[Huang, Li; Hu, Shencai] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Peoples R China.;[Yang, H; Wei, Hongping; Yang, Hang; Gondil, Vijay Singh; Zhou, Wanli] Chinese Acad Sci, Ctr Emerging Infect Dis, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Peoples R China.;[Yang, H; Wei, Hongping; Yang, Hang] Univ Chinese Acad Sci, Beijing, Peoples R China.
通讯机构：
[Yang, H; Wei, HP] C;[Yang, H; Wei, HP] U;Chinese Acad Sci, Ctr Emerging Infect Dis, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Peoples R China.;Univ Chinese Acad Sci, Beijing, Peoples R China.
关键词：
bacteriophage lysin;chimeric lysin;Streptococcus pneumoniae;choline-binding module;antimicrobial resistance
摘要：
Streptococcus pneumoniae is a leading pathogen for bacterial pneumonia, which can be treated with bacteriophage lysins harboring a conserved choline binding module (CBM). Such lysins regularly function as choline-recognizing dimers. Previously, we reported a pneumococcus-specific lysin ClyJ comprising the binding domain from the putative endolysin gp20 from the Streptococcus phage SPSL1 and the CHAP (cysteine, histidine-dependent amidohydrolase/peptidase) catalytic domain from the PlyC lysin. A variant of ClyJ with a shortened linker, i.e., ClyJ-3, shows improved activity and reduced cytotoxicity. Resembling typical CBM-containing lysins, ClyJ-3 dimerized upon binding with choline. Herein, we further report a choline-recognizing variant of ClyJ-3, i.e., ClyJ-3m, constructed by deleting its C-terminal tail. Biochemical characterization showed that ClyJ-3m remains a monomer after it binds to choline yet exhibits improved bactericidal activity against multiple pneumococcal strains with different serotypes. In an S. pneumoniae-infected bacteremia model, a single intraperitoneal administration of 2.32 μg/mouse of ClyJ-3m showed 70% protection, while only 20% of mice survived in the group receiving an equal dose of ClyJ-3 (P < 0.05). A pharmacokinetic analysis following single intravenously doses of 0.29 and 1.16 mg/kg of ClyJ-3 or ClyJ-3m in BALB/c mice revealed that ClyJ-3m shows a similar half-life but less clearance and a greater area under curve than ClyJ-3. Taken together, the choline-recognizing monomer ClyJ-3m exhibited enhanced bactericidal activity and improved pharmacokinetic proprieties compared to those of its parental ClyJ-3 lysin. Our study also provides a new way for rational design and programmed engineering of lysins targeting S. pneumoniae. Copyright © 2020 American Society for Microbiology. All Rights Reserved.
语种：
英文
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Influence of Lactobacillus buchneri on soybean curd residue co-conversion by black soldier fly larvae (Hermetia illucens) for food and feedstock production
作者：
Somroo, Abdul Aziz;Rehman, Kashif Ur;Zheng, Longyu;Cai, Minmin;Xiao, Xiaopeng;...
期刊：
Waste Management ,2019年86:114-122 ISSN：0956-053X
通讯作者：
Zhang, Jibin
作者机构：
[Somroo, Abdul Aziz; Rehman, Kashif Ur; Zheng, Longyu; Cai, Minmin; Zhang, Jibin; Yu, Ziniu; Xiao, Xiaopeng] Huazhong Agr Univ, Coll Life Sci & Technol, Natl Engn Res Ctr Microbial Pesticides, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China.;[Rehman, Kashif Ur] Govt Punjab, Poultry Res Inst, Livestock & Dairy Dev Dept, Rawalpindi, Pakistan.;[Hu, Shencai] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Hubei, Peoples R China.;[Gold, Moritz; Mathys, Alexander] Swiss Fed Inst Technol, Inst Food Nutr & Hlth, Lab Sustainable Food Proc, Zurich, Switzerland.;[Gold, Moritz] Swiss Fed Inst Aquat Sci & Technol Eawag, Dept Sanitat Water & Solid Waste Dev Sandec, Dubendorf, Switzerland.
通讯机构：
[Zhang, Jibin] H;Huazhong Agr Univ, Coll Life Sci & Technol, Natl Engn Res Ctr Microbial Pesticides, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China.
关键词：
Black soldier fly;Environment;Pollution;Soybean curd residues;Waste management
摘要：
Black soldier fly larvae (BSFL), Hermetia illucens (Diptera: Stratiomyidae) can reduce environmental pollution and convert organic wastes into biomass that is rich in protein and fat. The influence of the nutritional characteristics of organic waste on BSFL characteristics relevant for food and feed safety remains poorly understood. To evaluate the conversion of soybean curd residues (SCR) into high-quality animal-derived proteins and fats for human and livestock consumption, this study assessed the co-conversion efficacy, nutrient composition, safety, and anti-nutritional factor concentrations in BSFL after the development on SCR with Lactobacillus buchneri (L3-9). SCR was pretreated with L. buchneri (10(8) cfu/ml), and then BSFL was employed for conversion. BSFL fed with SCR and L. buchneri had a significantly higher dry mass reduction (55.7+/-0.9%), bioconversion rate (6.9+/-0.3%), crude protein content (55.3+/-0.6%), and fat content (30.0+/-0.6%) than SCR (49.0+/-0.7%, 5.0+/-0.3%, 52.8+/-0.3%, and 26.1+/-0.8%, respectively) and artificial feed (43.9+/-0.8%, 3.9+/-0.1%, 50.3+/-0.4%, and 24.3+/-0.4%, respectively). However, the feed conversion ratio (8.0+/-0.3), of BSFL fed with SCR and L. buchneri was lower than that of the BSFL fed with SCR (9.8+/-0.1) and artificial feed (11.1+/-0.5). In addition, BSFL had satisfactory concentrations of all essential amino acids and fatty acids required for human consumption as recommended by WHO/FAO/UNU. The heavy metals and anti-nutritional factor concentrations were within the safety intake levels for food and feedstock. Therefore, the addition of L. buchneri with BSFL on SCR did not only increase co-conversion performance but also enhanced the nutritional value of BSFL.
语种：
英文
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Evidence from O-18 feeding studies for hydroxyl group donor in the reaction catalyzed by cytidylate hydroxymethylase MilA
作者：
Chen Cheng;Gao TuLing;Zhao Gong;Deng ZiXin;Hu ShenCai;...
期刊：
科学通报(英文版) ,2013年58(8):864-868 ISSN：2095-9273
通讯作者：
He XinYi
作者机构：
[Gao TuLing; Zhao Gong; Chen Cheng; He XinYi; Deng ZiXin] Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200030, Peoples R China.;[Gao TuLing; Zhao Gong; Chen Cheng; He XinYi; Deng ZiXin] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200030, Peoples R China.;[Gao TuLing; Hu ShenCai] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.;[Xu, H. Howard] Calif State Univ Los Angeles, Dept Biol Sci, Los Angeles, CA 90032 USA.
通讯机构：
[He XinYi] S;Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200030, Peoples R China.
关键词：
5-hydroxymethylcytosine;hydroxymethylase;(H2O)-O-18 feeding;mildiomycin
摘要：
5-Hydroxymethylcytosine (5hmC) was present in T-even phage and mammalian DNA. 5hmC in phage is formed by hydroxymethylation of the cytosine base in deoxycytidylate (dCMP) by deoxycytidylate hydroxymethylase (CH), which uses the solvent water as the hydroxyl group donor. By contrast, 5hmC is formed in mammal zygotes by the oxidation of 5-methylcytosine (5mC). 5hmC was also present in a nucleoside antibiotic mildiomycin and its formation is governed by a cytidylate hydroxymethylase MilA. However, the catalytic mechanism remains unknown. In the present study, we purified His-tagged MilA and fed its in vitro reaction with H218O. The LC-MS analysis of the product revealed that 18O was incorporated into the hydroxymethylated CMP (HmCMP), and the secondary MS result of 18O-labeled HmCMP indicated that 18O was incorporated into the cytosine of HmCMP. The results demonstrate that MilA uses solvent water as the hydroxyl group donor like CH. Moreover, Thr102 of MilA was predicted as potential critical amino acid anchoring one molecule of water for hydroxylation. Finally, organizational context comparison in microbial genomes reveals that six homologous ORFs originally annotated as putative thymidylate synthase (TS) are more likely to be CMP hydroxymethylase. © 2013 The Author(s).
语种：
英文
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prfA-Like Transcription Factor Gene lmo0753 Contributes to L-Rhamnose Utilization in Listeria monocytogenes Strains Associated with Human Food-Borne Infections
作者：
Salazar, Joelle K.;Wu, Zhuchun;McMullen, P. David;Luo, Qin;Freitag, Nancy E.;...
期刊：
Applied and Environmental Microbiology ,2013年79(18):5584-5592 ISSN：0099-2240
通讯作者：
Zhang, Wei
作者机构：
[Salazar, Joelle K.; Zhang, Wei; Wu, Zhuchun] IIT, Inst Food Safety & Hlth, Bedford Pk, IL USA.;[McMullen, P. David; Freitag, Nancy E.] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA.;[Luo, Qin] Huazhong Normal Univ, Coll Life Sci, Wuhan, Peoples R China.;[Tortorello, Mary Lou] US FDA, Bedford Pk, IL USA.;[Zhang, Wei; Hu, Shencai] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Peoples R China.
通讯机构：
[Zhang, Wei] I;IIT, Inst Food Safety & Hlth, Bedford Pk, IL USA.
摘要：
Listeria monocytogenes is a food-borne bacterial pathogen and the causative agent of human and animal listeriosis. Among the three major genetic lineages of L. monocytogenes (i.e., LI, LII, and LIII), LI and LII are predominantly associated with food-borne listeriosis outbreaks, whereas LIII is rarely implicated in human infections. In a previous study, we identified a Crp/Fnr family transcription factor gene, lmo0753, that was highly specific to outbreak-associated LI and LII but absent from LIII. Lmo0753 shares two conserved functional domains, including a DNA binding domain, with the well-characterized master virulence regulator PrfA in L. monocytogenes. In this study, we constructed lmo0753 deletion and complementation mutants in two fully sequenced L. monocytogenes LII strains, 10403S and EGDe, and compared the flagellar motility, phospholipase C production, hemolysis, and intracellular growth of the mutants and their respective wild types. Our results suggested that lmo0753 plays a role in hemolytic activity in both EGDe and 10403S. More interestingly, we found that deletion of lmo0753 led to the loss of L-rhamnose utilization in EGDe, but not in 10403S. RNA-seq analysis of EGDe δ0753 incubated in phenol red medium containing L-rhamnose as the sole carbon source revealed that 126 (4.5%) and 546 (19.5%) out of 2,798 genes in the EGDe genome were up- and downregulated more than 2-fold, respectively, compared to the wild-type strain. Genes related to biotin biosynthesis, general stress response, and rhamnose metabolism were shown to be differentially regulated. Findings from this study collectively suggested varied functional roles of lmo0753 in different LII L. monocytogenes strain backgrounds associated with human listeriosis outbreaks. ©2013, American Society for Microbiology. All Rights Reserved.
语种：
英文
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Removal of Mercury from Wastewater by Adsorption Using Thiol-functionalized Eggshell Membrane
作者：
Cheng, Xianzhong* ;Hu, Cunjie;Cheng, Kuang;Wei, Benmei;Hu, Shencai
期刊：
Advanced Materials Research ,2010年113-116(229):22-26 ISSN：1022-6680
通讯作者：
Cheng, Xianzhong
作者机构：
[Cheng, Xianzhong; Wei, Benmei; Cheng, Kuang] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.;[Hu, Cunjie] Guilin Univ Technol, Coll Chem & Bioengn, Guillin 541004, Peoples R China.;[Hu, Shencai] Wuhan Polytech Univ, Sch Biol & Phamaceut, Wuhan, Peoples R China.
通讯机构：
[Cheng, Xianzhong] W;Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.
会议名称：
2010 International Conference of Environment Materials and Environment Management(2010年环境材料与环境管理国际学术会议 EMEM 2010)
会议时间：
2010-07-24
会议地点：
哈尔滨
会议主办单位：
[Cheng, Xianzhong;Cheng, Kuang;Wei, Benmei] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.^[Hu, Cunjie] Guilin Univ Technol, Coll Chem & Bioengn, Guillin 541004, Peoples R China.^[Hu, Shencai] Wuhan Polytech Univ, Sch Biol & Phamaceut, Wuhan, Peoples R China.
会议论文集名称：
2010 International Conference of Environment Materials and Environment Management(2010年环境材料与环境管理国际学术会议 EMEM 2010)论文集
关键词：
adsorption;eggshell membrane;thiol-functionalized;mercury ions;wastewater
摘要：
The thiol-functionalized eggshell membrane (TF-ESM) was prepared by esterification between thioglycolic acid (CH2SHCOOH) and oxygen-containing functional groups on eggshell membrane (ESM). A promising potential biosorbent, TF-ESM, was used for the removal of toxic mercury in wastewater. Aqueous of mercury ions removing properties by TF-ESM were studied through batch experiments. The results indicated that the modified ESM has greatly enhanced the adsorption capacity for Hg2+, the maximum capacity was increased more than 3-fold in comparison with the unmodified ESM, from 19.4 mg g-1 to 71.9 mg g-1. The optimum of pH value for Hg adsorption was in the range of 2-8, which the removing rate over 96%. The results obtained show that the novel thiol-functionalized eggshell membrane performed well the removal and recovery of mercury from low concentration wastewaters. © (2010) Trans Tech Publications, Switzerland.
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英文
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获自链霉菌060524发酵液细胞毒活性物质
作者：
胡申才;谭仁祥;庄令;闫莉萍;洪葵
期刊：
中国抗生素杂志 ,2009年34(3):193-195 ISSN：1001-8689
通讯作者：
Hu, S.-C.
作者机构：
[庄令; 闫莉萍; 洪葵] Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricuture Sciences, Haikou 571101, China;[谭仁祥] Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China;Department of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China;[胡申才] Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricuture Sciences, Haikou 571101, China, Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China, Department of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China
通讯机构：
[Hu, S.-C.] I;Institute of Tropical Bioscience and Biotechnology, , Haikou 571101, China
关键词：
海洋链霉菌;次级代谢产物;细胞毒活性;吲哚羧酸;茴香霉素类抗生素
摘要：
从链霉菌060524菌株的发酵液中共分离得到了12个化合物,以K562细胞检测细胞毒性实验,其中1-H-3-吲哚羧酸和1-H-3-吲哚羧酸甲酯2个化合物具中等强度细胞毒活性(10μg/ml≤IC_(50)≤20μg/ml);茴香霉素(anisomycin)和脱乙酰茴香霉素(deacetylanisomycin)2个化合物具有很强细胞毒活性(IC_(50)≤10μg/ml).另外,以HL-60作细胞凋亡实验,1-H-3-吲哚羧酸和脱乙酰茴香霉素在90μg/ml时显示了细胞凋亡作用.
语种：
中文
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Biotransformation of soybean isoflavones by a marine Streptomyces sp 060524 and cytotoxicity of the products
作者：
Hu, S. -C.;Hong, K.;Song, Y. -C.;Liu, J. -Y.;Tan, R. -X.*
期刊：
World Journal of Microbiology and Biotechnology ,2009年25(1):115-121 ISSN：0959-3993
通讯作者：
Tan, R. -X.
作者机构：
[Tan, R. -X.; Liu, J. -Y.; Hu, S. -C.; Song, Y. -C.] Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China.;[Hu, S. -C.; Hong, K.] Chinese Acad Trop Agr Sci, State Key Lab Trop Crop Biotechnol, Haikou 571101, Peoples R China.;[Hu, S. -C.] Wuhan Polytech Univ, Dept Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.
通讯机构：
[Tan, R. -X.] N;Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China.
关键词：
Biotransformation;beta-glucosidase;Cytotoxic bioactivity;Marine streptomyces;Isoflavones
摘要：
A marine Streptomyces sp. 060524 capable of hydrolyzing the glycosidic bond of isoflavone glycosides, was isolated by detecting its β-glucosidase activity. 5 isoflavone aglycones were isolated from culture filtrates in soybean meal glucose medium. They were identified as genistein (1), glycitein (2), daidzein (3), 3′,4′,5,7-tetrahydroxyisoflavone (4), and 3′,4′,7-trihydroxyisoflavone (5), based on UV, NMR and mass spectral analysis. The Streptomyces can selectively hydroxylate at the 3′-position in the daidzein and genistein to generate 3′-hydroxydaidzein and 3′-hydroxygenistein, respectively. The Strain biotransformed more than 90% of soybean isoflavone glycosides into their aglycones within 108 h. 3′-hydroxydaidzein and 3′-hydroxygenistein exhibited stronger cytotoxicity against K562 human chronic leukemia than daidzein and genistein.
语种：
英文
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一元固体二氧化氯泡腾片的工艺研究
作者：
张林霞;王奎涛;胡申才;王继刚
期刊：
化工科技市场 ,2007年30(8):20-22 ISSN：1009-4725
作者机构：
武汉工业学院生物与制药工程系,湖北武汉,430023;河北科技大学化学与制药工程学院;[王继刚; 胡申才; 张林霞] 武汉工业学院;[王奎涛] 河北科技大学
关键词：
一元二氧化氯;泡腾片;工艺
摘要：
本文对几种一元固体二氧化氯的片剂配方进行了研究,通过稳定性实验优选出较稳定的五种配方,对这五种配方压片后形成泡腾片.通过对泡腾片的质量检测得出配方五和六是较理想的一元固体二氧化氯泡腾片配方.
语种：
中文
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IFB-Lactam-1, a natural compound with anti-Gloeosporium kaki Hori activity
作者：
Hu, Shen-Cai* ;Mei, Li;Wang, Ji-Gang;Liu, Chang-Hong
期刊：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY ,2006年62(12):o5777-o5778 ISSN：2053-2296
通讯作者：
Hu, Shen-Cai
作者机构：
[Hu, Shen-Cai] Wuhan Polytech Univ, Dept Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.;Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210093, Peoples R China.
通讯机构：
[Hu, Shen-Cai] W;Wuhan Polytech Univ, Dept Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.
摘要：
The title compound, IFB-Lactam-1 (systematic name: 2,15-dihydroxy-7-methyl- 6-azabicyclo[11.3.0]hexadec-3-en-5-one), C16H27NO 3, is a newly characterized natural anti-Gloeosporium kaki Hori compound. It was isolated from the EtOAc extract of the fermentation broth of an endophytic fungus Trichoderma sp. from cabbage. It is a 13-membered macrocyclic lactam which shares a two-atom edge with a cyclopentanol ring. © 2006 International Union of Crystallography All rights reserved.
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英文
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