通讯机构：
[Cheng, QZ ; Ding, H ] W;Wuhan Polytech Univ, Coll Med & Hlth Sci, 68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.;Wuhan Univ, Sch Pharmaceut Sci, 185 Donghu Rd, Wuhan 430072, Hubei, Peoples R China.
关键词：
Epilepsy;Luteolin;Neuronal apoptosis;Neuroinflammation;TLR4/I kappa B alpha/NF-kappa B pathway
摘要：
Epilepsy represents a prevalent neurological disorder in the population, and the existing antiepileptic drugs (AEDs) often fail to adequately control seizures. Inflammation is recognized as a pivotal factor in the pathophysiology of epilepsy. Luteolin, a natural flavonoid extract, possesses anti-inflammatory properties and exhibits promising neuroprotective activity. Nevertheless, the precise molecular mechanisms underlying the antiepileptic effects of luteolin remain elusive. In this study, we established a rat model of epilepsy using pentylenetetrazole (PTZ) to induce seizures. A series of behavioral experiments were conducted to assess behavioral abilities and cognitive function. Histological techniques, including HE staining, Nissl staining, and TUNEL staining, were employed to assess hippocampal neuronal damage. Additionally, Western blotting, RT-qPCR, and ELISA were utilized to analyze the expression levels of proteins involved in the TLR4/I kappa B alpha/NF-kappa B signaling pathway, transcription levels of apoptotic factors, and levels of inflammatory cytokines, respectively. Luteolin exhibited a dosedependent reduction in seizure severity, prolonged the latency period of seizures, and shortened seizure duration. Furthermore, luteolin prevented hippocampal neuronal damage in PTZ-induced epileptic rats and partially restored behavioral function and learning and memory abilities. Lastly, PTZ kindling activated the TLR4/I kappa B alpha/ NF-kappa B pathway, leading to elevated levels of the cytokines TNF-alpha, IL-6 and IL-1 beta, which were attenuated by luteolin. Luteolin exerted anticonvulsant and neuroprotective activities in the PTZ-induced epileptic model. Its mechanism was associated with the inhibition of the TLR4/I kappa B alpha/NF-kappa B pathway, alleviating the immuneinflammatory response in the post-epileptic hippocampus.
摘要：
With the aging of human society, more and more elderly patients have to undergo surgery and anesthesia. Clinical observations have indicated from time to time that spinal anesthesia in the elderly appears to last longer than in young people, although there is limited research in this area and the mechanism is unclear at present time. This research work is expected to help understand the decline of local anesthetic metabolism in cerebrospinal fluid of elderly patients so as to help them with precise anesthesia and rapid rehabilitation. Twenty patients with spinal anesthesia in orthopedic lower limb surgery were selected to study the rate of drug metabolism in cerebrospinal fluid in two age groups, i.e.,18–30 years old and 75–90 years old. Ropivacaine in peripheral blood is used as a probe to reflect the speed of drug metabolism in cerebrospinal fluid. The contents of total Aβ protein and hyaluronic acid in the cerebrospinal fluid were investigated as well. The equivalent dose of ropivacaine anesthetizes the elderly group for a longer time. The metabolism rate of ropivacaine in an elderly patient was slower than that of a young patient. No significant difference in total Aβ protein between the two groups was observed while hyaluronic acid in the elderly group was significantly higher than that in the young group. This study shows that the dose of ropivacaine should be reduced when used for anesthesia in elderly patients. The cumulation of ropivacaine and HA appears to imitate the degeneration of central lymphatic circulation metabolism in elderly people.
摘要：
Nicotinamide mononucleotide (NMN) could reduce seizure intensity and improve cognitive function in epileptic animals. Additionally, NMN exhibited inhibitory effects on neuronal apoptosis. These therapeutic effects were found associated with the down‐regulation of fission proteins (Drp1 and Fis1) and the up‐regulation of fusion proteins (Mfn1 and Mfn2) through the SIRT1‐PGC‐1α pathway, thus promoting mitochondrial energy metabolism protection. These findings suggest that NMN intervention may serve as a novel potential therapeutic approach for epilepsy seizure (SE)‐induced cognitive impairment and behavioral disorders. Targeting the SIRT1‐PGC‐1α pathway represents a promising therapeutic strategy for addressing SE. Abstract Both human and animal experiments have demonstrated that energy metabolism dysfunction in neurons after seizures is associated with an imbalance in mitochondrial fusion/fission dynamics. Effective neuronal mitochondrial dynamics regulation strategies remain elusive. Nicotinamide mononucleotide (NMN) can ameliorate mitochondrial functional and oxidative stress in age‐related diseases. But whether NMN improves mitochondrial energy metabolism to exert anti‐epileptic effects is unclear. This study aims to clarify if NMN can protect neurons from pentylenetetrazole (PTZ) or Mg2+‐free‐induced mitochondrial disorder and apoptosis via animal and cell models. We established a continuous 30‐day PTZ (37 mg/kg) intraperitoneal injection‐induced epileptic mouse model and a cell model induced by Mg2+‐free solution incubation to explore the neuroprotective effects of NMN. We found that NMN treatment significantly reduced the seizure intensity of PTZ‐induced epileptic mice, improved their learning and memory ability, and enhanced their motor activity and exploration desire. At the same time, in vitro and in vivo experiments showed that NMN can inhibit neuronal apoptosis and improve the mitochondrial energy metabolism function of neurons. In addition, NMN down‐regulated the expression of mitochondrial fission proteins (Drp1 and Fis1) and promoted the expression of mitochondrial fusion proteins (Mfn1 and Mfn2) by activating the SIRT1‐PGC‐1α pathway, thereby inhibiting PTZ or Mg2+‐free extracellular solution‐induced mitochondrial dysfunction, cell apoptosis, and oxidative stress. However, combined intervention of SIRT1 inhibitor, Selisistat, and PGC‐1α inhibitor, SR‐18292, eliminated the regulatory effect of NMN pre‐treatment on mitochondrial fusion and fission proteins and apoptosis‐related proteins. Therefore, NMN intervention may be a new potential treatment for cognitive impairment and behavioral disorders induced by epilepsy, and targeting the SIRT1‐PGC‐1α pathway may be a promising therapeutic strategy for seizures.
摘要：
American Journal of Alzheimer's Disease & Other Dementias®, Volume 39, Issue , January-December 2024. <br/>ObjectivesTo examine the relationship between hearing impairment and cognitive function and the mediating role of social isolation and depression. Methods: Data came from the 2018 China Health and Retirement Longitudinal Study wave. A self-reported item, a composite index, the 10-item Center for Epidemiological Studies Depression Scale, and the Mini-Mental State Exam were used to measure hearing impairment, social isolation, depression, and cognitive function, respectively. Mediation analysis was performed. Results: 6799 participants were included. For participants reporting mild hearing impairment and severe hearing impairment, there were significant direct and indirect effects on cognitive function. Social isolation mediated 2.75% and 6.33% of the relationship between mild hearing impairment, severe hearing impairment, and cognitive function, respectively. The direct effect of hearing impairment outweighed the mediation effect of social isolation on cognitive function. Conclusions: Decreased cognitive function linked to hearing impairment might benefit from addressing hearing impairment and social isolation in older adults.
通讯机构：
[Wei, N ] W;Wuhan Polytech Univ, Coll Med & Hlth Sci, Dept Rehabil Sci, Wuhan, Hubei, Peoples R China.
关键词：
Dynapenia;anthropometric measurements;cut-off values;receiver operating characteristic curve analysis;the five times sit-to-stand test
摘要：
PURPOSE: This study evaluated whether anthropometric measurements and the five times sit-to-stand test could be used to identify dynapenia. The cut-off values of accurate screening tools for identifying dynapenia were also established. MATERIALS AND METHODS: This was a cross-sectional study conducted on individuals ≥ 60 years old (N = 529). All participants underwent handgrip strength measurement, anthropometric measurements and the five times sit-to-stand test. The participants whose handgrip strength was < 28 kg for men and < 18 kg for women were considered to have dynapenia. The association between the recorded variables and dynapenia was determined using logistic regression, and cut-off values were established by performing the Receiver Operating Characteristic curve analysis. RESULTS: The prevalence of dynapenia was 35.42% in men and 25.61% in women. For males, both calf circumference (≤ 35.2 cm) and the five times sit-to-stand test (≥ 14.6 s) could be used as accurate tools for dynapenia. For females, only the five times sit-to-stand test (≥ 11.8 s) had sufficient accuracy to be used as a screening tool for dynapenia. CONCLUSIONS: The five times sit-to-stand test was an accurate screening tool for identifying dynapenia. The calf circumference could be only used as a screening tool in males.
摘要：
Objectives: This study aimed to investigate the associations between social isolation, loneliness, and motoric cognitive risk syndrome (MCR) among older adults in China.Methods: Data were obtained from the China Health and Retirement Longitudinal Study in the 2011 and 2015 waves. Social isolation and loneliness were measured by an index and an item, and MCR was defined as subjective cognitive complaints and slow gait. Multivariable logistic regression analyses were performed to examine the associations between social isolation, loneliness, and MCR by gender.Results: Of 3251 eligible participants, the incidence of MCR was 10.03%. Social isolation and loneliness were not significantly associated with incident MCR in men. Loneliness was positively associated with incident MCR in women (OR: 1.45, 95% CI: 1.05, 2.01), while social isolation was not.Conclusions: Loneliness is associated with incident MCR among female older adults in China. More attention is advised to be paid to loneliness among female older adults, to hold promise for the prevention and reduction of MCR.
摘要：
Phthalides are a class of unique compounds such as ligustilide, butylphthalide and butyldenephthalide, which have shown to possess multiple bioactivities in new drug research and development. Phthalides are naturally distributed in different plants that have been utilized as herbal treatments for various ailments with a long history in Asia, Europe and North America. Their extensive biological activity has led to a dramatic increase in the study of phthalide compounds in recent years. This review summarizes the latest research progress of plant-derived phthalides, and a total of 133 phthalide compounds are described based on the characteristics of chemical structures. Pharmacological properties of plant-derived phthalides are associated with hemorheological improvement, vascular function modulation and central nervous system protection. Potential treatments for a variety of diseases mainly including cardio-cerebrovascular disorders and neurological complications such as Alzheimer's disease are also concluded. In addition, key metabolic pathways have been clearly elucidated. Further investigations on the molecular mechanisms involved in biological activity are recommended for offering new insights into profound comprehension of phthalide applications.
摘要：
To summarize the nursing experience of treating pediatric fulminant myocarditis with extracorporeal membrane oxygenation (ECMO). The intensive care unit of our hospital treated 6 children with fulminant myocarditis with ECMO from 2019 to 2022. The main nursing measures included establishing an ECMO rescue team, preparing before initiation of ECMO, management of arterial and venous catheters, enteral nutrition support, reducing the risk of infection aggravation, anticoagulation management, prevention of bleeding and thrombosis, management of ECMO pump failure, and post-ECMO care. One child's family abandoned treatment and left the hospital, while the other 5 children were transferred to the cardiovascular department after stable weaning from ECMO and continued treatment, with good condition, and eventually discharged. Pediatric fulminant myocarditis has a high mortality rate, but detailed evaluation and nursing care can improve the outcome of these patients.
摘要：
Background: Migraine is a common neurovascular disorder with typical throbbing and unilateral headaches, causing a considerable healthcare burden on the global economy. This research aims to prepare chitosan-alginate (CS-AL) nanoparticles (NPs) containing Foshousan oil (FSSO) and investigate its potential therapeutic effects on the treatment of migraine.Methods: FSSO-loaded CS-AL NPs were prepared by using the single emulsion solvent evaporation method. Lipopolysaccharide (LPS)-stimulated BV-2 cells and nitroglycerin (NTG)-induced migraine mice were further used to explore anti-migraine activities and potential mechanisms of this botanical drug.Results: FSSO-loaded CS-AL NPs (212.1 & PLUSMN; 5.2 nm, 45.1 & PLUSMN; 6.2 mV) had a well-defined spherical shape with prolonged drug release and good storage within 4 weeks. FSSO and FSSO-loaded CS-AL NPs (5, 10, and 15 & mu;g/mL) showed anti-inflammatory activities in LPS-treated BV-2 cells via reducing the levels of pro-inflammatory cytokines such as tumor necrosis factor-& alpha; (TNF-& alpha;), interleukin-1 & beta; (IL-1 & beta;), interleukin-6 (IL-6), and nitric oxide (NO), but elevating interleukin-10 (IL-10) expressions. Moreover, FSSO-loaded CS-AL NPs (52 and 104 mg/kg) raised pain thresholds against the hot stimulus and decreased acetic acid-induced writhing frequency and foot-licking duration in NTG-induced migraine mice. Compared with the model group, calcitonin gene-related peptide (CGRP) and NO levels were downregulated, but 5-hydroxytryptamine (5-HT) and endothelin (ET) levels were upregulated along with rebalanced ET/NO ratio, and vasomotor dysfunction was alleviated by promoting cerebral blood flow (CBF) in the FSSO-loaded CS-AL NPs (104 mg/kg) group.Conclusion: FSSO-loaded CS-AL NPs could attenuate migraine via inhibiting neuroinflammation in LPS-stimulated BV-2 cells and regulating vasoactive substances in NTG-induced migraine mice. These findings suggest that the FSS formula may be exploited as new phytotherapy for treating migraine.
摘要：
Background: Evidence has suggested that sensation and socio-psychological factors may be associated with cognitive impairment separately in older adults. However, the association between those risk factors and cognitive impairment is still unknown.Objective: To investigate the association between sensation, perception, negative sociopsychological factors, and cognitive impairment in institutionalized older adults.Methods: From two public aged care facilities, 215 participants were investigated. The Minimental State Examination was applied to assess cognitive function. The sensory function was bifurcated into auditory and somatosensory realms which were evaluated using pure tone audiometry and Nottingham Sensory Assessment, respectively. Albert's test, left and right resolution, and visuospatial distribution were used to evaluate perception. Depression and social isolation were selected as negative socio-psychological factors and were evaluated by the Geriatric Depression Scale and the Lubben Social Network Scale. The multivariate analysis was performed utilizing binary logistic regression.Results: Participants with moderately severe or severe hearing loss exhibited significant cognitive impairment compared to those with mild hearing loss. It was observed that perceptual dysfunction and depression were independently related to cognitive impairment. However, there was no significant association between somatosensory function, social isolation, and cognitive impairment in the institutionalized older adults.Conclusion: More profound hearing loss, abnormal perception, and depression are associated with cognitive impairment in older adults. Subsequent research endeavors should delve into the causal mechanisms underpinning these associations and explore whether combined interventions have the potential to postpone the onset of cognitive impairment.
作者机构：
[Zhou, Jinbo; Li, Hao; Kang, Zhen; Zeng, Shan; Sheng, Zhongyin] Wuhan Polytech Univ, Sch Math & Comp Sci, Wuhan 430023, Peoples R China.;[Chen, Yulong] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan 430023, Peoples R China.
通讯机构：
[Shan Zeng] S;School of Mathematics and Computer Science, Wuhan Polytechnic University, Wuhan 430023, China<&wdkj&>Author to whom correspondence should be addressed.
关键词：
polished rice;RoI;YOLOv5;YOLACT
摘要：
The problem of small and multi-object polished rice image segmentation has always been one of importance and difficulty in the field of image segmentation. In the appearance quality detection of polished rice, image segmentation is a crucial part, directly affecting the results of follow-up physicochemical indicators. To avoid leak detection and inaccuracy in image segmentation qualifying polished rice, this paper proposes a new image segmentation method (YO-LACTS), combining YOLOv5 with YOLACT. We tested the YOLOv5-based object detection network, to extract Regions of Interest (RoI) from the whole image of the polished rice, in order to reduce the image complexity and maximize the target feature difference. We refined the segmentation of the RoI image by establishing the instance segmentation network YOLACT, and we eventually procured the outcome by merging the RoI. Compared to other algorithms based on polished rice datasets, this constructed method was shown to present the image segmentation, enabling researchers to evaluate polished rice satisfactorily.
作者机构：
[Ming, Yu] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan 430023, Hubei, Peoples R China.;[Wu, Zhouyang; Chu, Shujuan; Yang, Kai; Zhang, Zhao; Wu, ZY; Zhang, Z] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan 430022, Peoples R China.
通讯机构：
[Wu, ZY ; Zhang, Z] H;Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan 430022, Peoples R China.
摘要：
To evaluate the comparative efficacy and safety of different intubation devices on intubation outcomes in pediatric intubation. We identified relevant studies from previous meta-analyses and literature retrieval in PubMed, EMBASE, and Cochrane Library. The primary outcome was the first-pass success (FPS), and the secondary outcome included the time to intubation (TTI) and the risk of local complications (LC). Network meta-analysis was performed using STATA 14.0. Twenty-three randomized comparative trials (RCTs) including 12 devices were included. Compared with Macintosh, Airtraq (odds ratio [OR] = 13.05, 95% confidence interval [CI] = 4.68 to 36.38), Miller (OR = 4.77, 95%CI = 1.32 to 17.22), Glidescope (OR = 2.76, 95%CrI = 1.60 to 4.75) and McGrath (OR = 4.61, 95%CI = 1.18 to 17.99) obtained higher PFS. Meanwhile, Airtraq was superior to Glidescope (OR = 0.21, 95%CI = 0.07 to 0.65) for PFS. For TTI, Canada was superior to other intubation devices, as well as CMAC was superior to TruViewEVO2, Glidescope, and StorzDCI. Airtraq lowered the risk of LC compared with Macintosh and Pentax but there was no statistical difference between Airtraq and KingVision. Airtraq may be the optimal option for FPS, Canada for TTI, and KingVision for LC in pediatric intubation.
摘要：
As the research on deep learning methods gradually progresses, more and more classification models are applied in the classification of hyperspectral image (HSI). High-dimensional and low-resolution characteristics of HSI, however, make it difficult for conventional models to process its data effectively. In this article, a novel HSI classification model, namely, spatial–spectral pyramid network (SSPN), is designed by combining a 3-D convolutional neural network (3D CNN) with feature pyramid structure. SSPN taking advantage of 3-D convolution coupled with multiscale convolutional extraction is used to obtain a large set of diverse spatial–spectral features. Multiscale interfusion is also applied in SSPN to enrich the features contained in a single feature map and to improve the sensitivity on HSI spatial–spectral information, allowing it to better learn spatial–spectral features. Moreover, the losses of each combination based on multiscale interfusion are calculated via weighted average, which enables SSPN to avoid the excessive influence of single combination in the updating of model parameters. Four HSI public datasets and several comparison models are employed to validate the classification effect of SSPN. Experimental results show that SSPN achieves the highest overall accuracy (OA) in all datasets compared with other classification models, with 100%, 98.8%, 99.8%, and 98.7% on the datasets of Chikusei, Pavia University, Botswana, and Houston 2013, respectively. SSPN is demonstrated to possess higher classification accuracy and better generalization performance on HSI.
通讯机构：
[Yuanyuan Li] K;Key Laboratory of Environment and Health (Huazhong University of Science and Technology), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
摘要：
Background: Selenium concentration of one spot urine sample cannot reflect selenium status during whole pregnancy. Studies on variations of urinary selenium concentration at different stages of pregnancy are limited. Aim: To assess variations of urinary selenium concentrations during three trimesters of pregnancy and to explore the influencing factors. Methods: This study included 2613 pregnant women from a birth cohort study (Wuhan, China) enrolled between October 2014 and October 2016. Selenium concentrations of urine samples collected at three trimesters were measured. We used a generalized linear mixed effects model to observe the changes in urinary selenium concentration during pregnancy and its influencing factors. Results: The median value (range) of gestational weeks at urine sample collection was 11 (9 14), 24 (15 27), and 34 (28 41) respectively. Urine selenium concentration varied across trimesters (geometric mean: 16.34, 17.65 and 18.83 mu g/g creatinine, respectively), with an upward trend (beta = -0.145, 95%CI: -0.164, 0.126) (beta = 0.066, 95%CI: 0.083, 0.048). The concentrations of urinary selenium increased with the increasing of educational level [beta (95%CI): <= 9 years = -0.105 (-0.163, -0.047); 10-12 years = -0.086(-0.126, -0.047); > 12 years = reference]. Pregnant women who rarely or only took multivitamins in the first trimester [beta (95% CI): rarely = -0.076 (-0.144, -0.007); only in the first three months of pregnancy = -0.104 (-0.170, -0.038); always = reference], or were not exposed to passive smoking during pregnancy(beta = -0.093, 95% CI: -0.173, -0.014), or exercised three to four days per week for the first three months before delivery(beta = -0.074, 95% CI: -0.140, -0.008) had lower urinary selenium concentrations. Pregnant women who took calcium supplements after the third month of pregnancy had higher urinary selenium levels(beta = 0.114, 95% CI: 0.059, 0.169). Conclusions: Urine selenium concentrations of pregnant women showed an upward trend across trimesters. Educational level, calcium or multivitamin supplementation, passive smoking, and physical exercise might impact urine selenium levels.
期刊：
International Journal of Clinical Practice,2022年2022 ISSN：1368-5031
通讯作者：
Zhang, H.
作者机构：
[Zhang, Hongping; Zhao, Yinshaung] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan 430023, Peoples R China.;[Han, Mo; Wei, Feng] Ctr Dis Prevent & Control Huangpi Dist Wuhan, Wuhan 430300, Peoples R China.;[Chen, Jianquan] Dept Dis Control Hlth & Family Planning Commiss H, Wuhan 430300, Peoples R China.;[Peng, Songxu] Cent South Univ, Xiangya Sch Publ Hlth, Xiangya Sch Med, Dept Maternal & Child Hlth, Changsha 410008, Peoples R China.;[Du, Yukai] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Social Med & Hlth Management, Wuhan 430030, Peoples R China.
通讯机构：
[Hongping Zhang; Mo Han; Yinshaung Zhao; Feng Wei] C;[Yukai Du; Songxu Peng; Jianquan Chen] D;College of Medicine and Health Science,Wuhan Polytechnic University,Wuhan 430023,China<&wdkj&>Department of Disease Control,Health and Family Planning Commission of Huangpi District of Wuhan,Wuhan 430300,China<&wdkj&>Department of Maternal and Child Health,Xiangya School of Public Health,Xiangya School of Medicine,China<&wdkj&>Centers for Disease Prevention & Control of Huangpi District of Wuhan,Wuhan 430300,null,China<&wdkj&>Department of Social Medicine and Health Management,School of Public Health,Tongji Medical College,China
关键词：
Introduction;Materials and Methods;Results;Discussion;Conclusion;Abstract;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interests;Authors’ Contributions;Funding Statement;Acknowledgements;Acknowledgments;Supplementary Materials;Reference;Dataset Description;Dataset Files;Abstract;Introduction;Introduction and Materials;Introduction and Methods;Materials;Materials and Methods;Methods;Results;Discussion;Results and Discussion;Discussion and Conclusion;Results and Conclusion;Conclusion;Conclusions;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interest;Authors’ Contributions;Funding Statement;Acknowledgements;Supplementary Materials;References;Appendix;Abbreviations;Preliminaries;Introduction and Preliminaries;Notation;Proof of Theorem;Proofs;Analysis of Results;Examples;Numerical Example;Applications;Numerical Simulation;Model;Model Formulation;Systematic Palaeontology;Nomenclatural Acts;Taxonomic Implications;Experimental;Synthesis;Overview;Characterization;Background;Experimental;Theories;Calculations;Model Verification;Model Implementation;Geographic location;Study Area;Geological setting;Data Collection;Field Testing;Data and Sampling;Dataset;Literature Review;Related Works;Related Work;System Model;Methods and Data;Experimental Results;Results and Analysis;Evaluation;Implementation;Case Presentation;Case Report;Search Terms;Case Description;Case Series;Background;Limitations;Additional Points;Case;Case 1;Case 2 etc.;Concern Details;Retraction Details;Copyright;Related Articles
期刊：
International Journal of Environmental Research and Public Health,2022年19(15):9509- ISSN：1661-7827
通讯作者：
Feng Ding
作者机构：
[Gao, Xudong] Wuhan Polytech Univ, Coll Med & Hlth Sci, Dept Nursing, Wuhan 430023, Peoples R China.;[Ding, Feng] Wuhan Univ, Sch Informat Management, Lib & Informat Sci, Wuhan 430072, Peoples R China.;[Ai, Ting] Wuhan Polytech Univ, Coll Med & Hlth Sci, Psychol Counseling Ctr, Wuhan 430023, Peoples R China.
通讯机构：
[Feng Ding] L;Library and Information Science, School of Information Management, Wuhan University, Wuhan 430072, China<&wdkj&>Author to whom correspondence should be addressed.
关键词：
COVID-19;elderly people;information avoidance;information overload;health information
摘要：
Background: A worrying phenomenon has emerged in recent years: a growing number of people have stopped seeking coronavirus disease 2019 (COVID-19) information and have started deliberately avoiding it. Even though the virulence of COVID-19 has now weakened, the proportion of severe illnesses and deaths in elderly people is still much higher than in other age groups. However, no study has focused on this topic. This is the first study to explore the level of COVID-19 information avoidance among elderly people, and to identify the barriers and potential factors associated therewith. Methods: Convenience sampling was used to recruit 907 elderly people in Wuhan, China. Data collection measures included a sociodemographic questionnaire, health information avoidance scale, information overload scale, general self-efficacy scale, and health anxiety inventory. Results: A total of 72.3% of elderly participants reported COVID-19 information avoidance. Regarding COVID-19-related information reading habits, 44.5% of the elderly only read the title, 16.0% merely skimmed through the content, and 22.9% skipped all relevant information. The most common reasons for this result were information overload (67.5%), underestimation of the infection risk (58.1%), and uselessness of information (56.4%). The main factors associated with COVID-19 information avoidance were recorded as information overload, age, health anxiety, and children (p < 0.05). Conclusions: China should strengthen its health communication regarding COVID-19 in accordance with the characteristics of elderly people, adopt more attractive publicity methods on traditional media, improve censorship about health information, and pay more attention to the childless elderly and the elderly aged 80 and above.
