作者机构：
[Fen Teng] Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;[Longxia Hu; Jiaqing Wang; Yi Dai; Lihong Bao; Yun Yang; Tingting Jiao; Fei Luo; Yali Yang; Zixi Wang; Xiaoping Yang; Shengli Yang] Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;[Deying Hu; Yilan Liu; Yanhong Han; Xiaoping Ding] Department of Nursing, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;[Wenbin Liu; Hongling Zhang; Qingzhou Cheng] College of Medicine and Health Science, Wuhan Polytechnic University, Wuhan, China
通讯机构：
[Deying Hu] D;[Wenbin Liu] C;Department of Nursing, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China<&wdkj&>College of Medicine and Health Science, Wuhan Polytechnic University, Wuhan, China
关键词：
attitude;knowledge;living will;malignant tumor;palliative care
摘要：
Given the suboptimal quality of end-of-life care among patients with cancer in China, promoting living wills is critical in this population. Living wills ensure that individuals can receive the medical care they desire during the terminal phase of an illness, maintain their dignity, and ultimately achieve a good death. However, current awareness and attitudes about living wills among Chinese patients with cancer remain unclear. We administered a questionnaire survey on living wills to patients with malignant tumors to assess their most important needs and increase understanding about living wills.
In this cross-sectional study using convenience sampling, inpatients with malignant tumors in Wuhan completed our questionnaire between July 2020 and June 2021. We collected patients' sociodemographic characteristics and details regarding their knowledge and attitudes about living wills.
Among 213 patients with malignant tumors, 114 (53.52%) had heard of living wills; 125 (58.69%) expressed their willingness to sign the “Five Wishes” living will document after learning about it through the questionnaire. Patients with malignant tumors had a high level of desire for the following living will items: the lives of family and friends return to normal as soon as possible after their death, maintaining personal hygiene and dignity, and remaining pain-free. The knowledge level of patients with malignant tumors was related to their educational level ( p < 0.05) and self-care ability ( p < 0.05).
Patients with malignant tumors have a high need for comfort, cleanliness, and pain relief in the terminal stages. Patients with a higher level of education and those with poorer self-care ability had greater knowledge and acceptance of living wills. Promotion can first be targeted toward more highly educated patients and can then be gradually expanded to other groups.
期刊：
FRONTIERS IN PSYCHIATRY,2025年16:1588065 ISSN：1664-0640
作者机构：
[Yihan, He; Luo, Jiyu; Xu, Ao; Qiu, Dongmei; Huang, Haiyun; Peng, Xiaorui; Zhou, Yujia; Hu, Xiang; Zhang, Hongling] College of Medicine and Health Science, Wuhan Polytechnic University, Wuhan, Hubei Province, China;[Zhou, Hui] Huangshi Hospital of Traditional Chinese Medicine, Huangshi, China;[Xu, Lingyun; Li, Yang] School of Life Science and Technology, Wuhan Polytechnic University, Wuhan, Hubei Province, China;[Li, Yuanyuan] Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hebei Province, China
关键词：
family functioning;stressful life events;Second trimester of pregnancy;Depression;Mediation
摘要：
Background: In current research on prenatal depression among pregnant women, the role of family functioning is crucial yet often overlooked. Specifically, in the field of maternal mental health, relatively limited attention has been given to the psychological well-being of women during the second trimester of pregnancy. This study aims to assess the depression, family functioning, and stressful life events of women in their second trimester, and to explore whether family functioning mediates the relationship between stressful events and depressive symptoms. Methods: A questionnaire survey was conducted with 3,386 pregnant women from the Wuhan Healthy Baby Birth Cohort. Participants completed the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10), the Family APGAR Index, and the 18-item Stressful Life Events Scale. Structural equation modeling was applied to analyze the data. Results: The findings revealed significant interrelationships among depression, family functioning, and stressful life events. Family functioning was found to partially mediate the relationship between stressful life events and depressive symptoms during the second trimester, explaining 21.9% of the variance. Conclusions: These findings suggest that improving family functioning and fostering communication can help reduce depressive symptoms during the second trimester, supporting maternal mental health.
摘要：
Both colchicine (Col) and loxoprofen sodium (LS) are first-line drugs for gouty arthritis (GA). Dissolvable microneedles (DMNs) represent an innovative transdermal drug delivery system (TDDS) that maximizes the therapeutic effect of drugs. In this paper, a novel TDDS of combined Col with LS loaded in DMNs (Col-LS-DMNS) was prepared to treat GA. To assess the synergistic effects of Col and LS, cell viability assays were conducted using monosodium urate (MSU)-induced HaCaT cells. The optimization of the Col-LS-DMNs formulation was carried out through sealing membrane puncture tests, single-factor experiments, and Box-Behnken response surface methodology. The quality of Col-LS-DMNs was assessed using high-performance liquid chromatography (HPLC), scanning electron microscopy (SEM), sealing membrane puncture tests, in vitro mouse skin puncture experiments, and Franz diffusion cell assays. The therapeutic effect of Col-LS DMNs on GA through animal experiments. Results demonstrated that Col and LS exhibit a synergistic effect, with optimal mass ratio of 1:1. The optimal formulation included PVP K30 and CMC Na at a mass ratio of 10:1, with 63 % water content and a mixed dosage of Col and LS of 42 mg. The drug content in Col-LS-DMNs was (19.11 ± 0.65) μg of Col and (20.69 ± 0.89) μg of LS per tablet. SEM imaging revealed that the needle tips were conical. Additionally, Col-LS-DMNs exhibited favorable mechanical properties and caused minimal skin damage. After 24 h, the cumulative permeation amount was (21.55 ± 19.49) μg/cm2. Col-LS-DMNs significantly reduced MSU-induced ankle swelling and decreased serum concentrations of TNF-α, IL-6, and IL-1β in rats. In conclusion, Col-LS-DMNs represent a promising new treatment modality for GA.
Both colchicine (Col) and loxoprofen sodium (LS) are first-line drugs for gouty arthritis (GA). Dissolvable microneedles (DMNs) represent an innovative transdermal drug delivery system (TDDS) that maximizes the therapeutic effect of drugs. In this paper, a novel TDDS of combined Col with LS loaded in DMNs (Col-LS-DMNS) was prepared to treat GA. To assess the synergistic effects of Col and LS, cell viability assays were conducted using monosodium urate (MSU)-induced HaCaT cells. The optimization of the Col-LS-DMNs formulation was carried out through sealing membrane puncture tests, single-factor experiments, and Box-Behnken response surface methodology. The quality of Col-LS-DMNs was assessed using high-performance liquid chromatography (HPLC), scanning electron microscopy (SEM), sealing membrane puncture tests, in vitro mouse skin puncture experiments, and Franz diffusion cell assays. The therapeutic effect of Col-LS DMNs on GA through animal experiments. Results demonstrated that Col and LS exhibit a synergistic effect, with optimal mass ratio of 1:1. The optimal formulation included PVP K30 and CMC Na at a mass ratio of 10:1, with 63 % water content and a mixed dosage of Col and LS of 42 mg. The drug content in Col-LS-DMNs was (19.11 ± 0.65) μg of Col and (20.69 ± 0.89) μg of LS per tablet. SEM imaging revealed that the needle tips were conical. Additionally, Col-LS-DMNs exhibited favorable mechanical properties and caused minimal skin damage. After 24 h, the cumulative permeation amount was (21.55 ± 19.49) μg/cm2. Col-LS-DMNs significantly reduced MSU-induced ankle swelling and decreased serum concentrations of TNF-α, IL-6, and IL-1β in rats. In conclusion, Col-LS-DMNs represent a promising new treatment modality for GA.
期刊：
Saudi Pharmaceutical Journal,2024年32(6):102100 ISSN：1319-0164
通讯作者：
Xu, LY;Qiu, YS
作者机构：
[Li, Junjie; Jiang, Peipei; Xu, Lingyun; Han, Di; Liu, Mingxue; Wang, Yingzhou] Wuhan Polytech Univ, Sch Life Sci & Technol, Xuefu South Rd 68,Changqing Garden, Wuhan 430023, Peoples R China.;[Zhang, Hongling] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan 430023, Peoples R China.;[Qiu, Yinsheng] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Xuefu South Rd 68,Changqing Garden, Wuhan 430023, Peoples R China.
通讯机构：
[Xu, LY ; Qiu, YS ] W;Wuhan Polytech Univ, Sch Life Sci & Technol, Xuefu South Rd 68,Changqing Garden, Wuhan 430023, Peoples R China.;Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Xuefu South Rd 68,Changqing Garden, Wuhan 430023, Peoples R China.
关键词：
Baicalin;Microemulsion-based gel;Skin penetration and retention;Gouty arthritis;Analgesic and anti-inflammatory activity
摘要：
We previously demonstrated that baicalin had efficacy against gouty arthritis (GA) by oral administration. In this paper, a novel baicalin-loaded microemulsion-based gel (B-MEG) was prepared and assessed for the transdermal delivery of baicalin against GA. The preparation method and transdermal capability of B-MEG was screened and optimized using the central composite design, Franz diffusion cell experiments, and the split-split plot design. Skin irritation tests were performed in guinea pigs. The anti-gout effects were evaluated using mice. The optimized B-MEG comprised of 50 % pH 7.4 phosphate buffered saline, 4.48 % ethyl oleate, 31.64 % tween 80, 13.88 % glycerin, 2 % borneol, 0.5 % clove oil and 0.5 % xanthan gum, with a baicalin content of (10.42 ± 0.08) mg/g and particle size of (15.71 ± 0.41) nm. After 12 h, the cumulative amount of baicalin permeated from B-MEG was (672.14 ± 44.11) μg·cm−2. No significant skin irritation was observed following B-MEG application. Compared to the model group, B-MEG groups significantly decreased the rate of auricular swelling (P < 0.01) and number of twists observed in mice (P < 0.01); and also reduced the rate of paw swelling (P < 0.01) and inflammatory cell infiltration in a mouse model of GA. In conclusion, B-MEG represents a promising transdermal carrier for baicalin delivery and can be used as a potential therapy for GA.
We previously demonstrated that baicalin had efficacy against gouty arthritis (GA) by oral administration. In this paper, a novel baicalin-loaded microemulsion-based gel (B-MEG) was prepared and assessed for the transdermal delivery of baicalin against GA. The preparation method and transdermal capability of B-MEG was screened and optimized using the central composite design, Franz diffusion cell experiments, and the split-split plot design. Skin irritation tests were performed in guinea pigs. The anti-gout effects were evaluated using mice. The optimized B-MEG comprised of 50 % pH 7.4 phosphate buffered saline, 4.48 % ethyl oleate, 31.64 % tween 80, 13.88 % glycerin, 2 % borneol, 0.5 % clove oil and 0.5 % xanthan gum, with a baicalin content of (10.42 ± 0.08) mg/g and particle size of (15.71 ± 0.41) nm. After 12 h, the cumulative amount of baicalin permeated from B-MEG was (672.14 ± 44.11) μg·cm−2. No significant skin irritation was observed following B-MEG application. Compared to the model group, B-MEG groups significantly decreased the rate of auricular swelling (P < 0.01) and number of twists observed in mice (P < 0.01); and also reduced the rate of paw swelling (P < 0.01) and inflammatory cell infiltration in a mouse model of GA. In conclusion, B-MEG represents a promising transdermal carrier for baicalin delivery and can be used as a potential therapy for GA.
期刊：
FRONTIERS IN PSYCHOLOGY,2024年15:1341215 ISSN：1664-1078
通讯作者：
Qi, L
作者机构：
[Zhang, Hongling; Qi, Ling; Nie, Rong] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan, Peoples R China.;[Du, Yukai] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Maternal & Child Hlth, Tongji Med Coll, Wuhan, Hubei, Peoples R China.
通讯机构：
[Qi, L ] W;Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan, Peoples R China.
关键词：
children and adolescents;hearing impairment;positive coping;resilience;self-esteem
摘要：
Background: The level of self-esteem in adolescents appears to be contingent upon their satisfaction across various domains of life, exerting a notable influence on their mental wellbeing. The purposes of this study were to further validate the influence of resilience and positive coping strategy on their self-esteem and to explore the mediating effect of positive coping strategy in the relationship between resilience and self-esteem. Methods: A total of 657 children and adolescents with a hearing impairment from 14 deaf/special schools in Hubei province completed measures of self-esteem, resilience, and positive coping. Results: (1) Self-esteem is positively correlated with resilience and positive coping, (2) resilience is a significant predictor of self-esteem, and (3) the association between resilience and self-esteem was partly mediated by a positive coping strategy. Conclusion: This study indicated the partly mediating effects of positive coping strategy on the association between resilience and self-esteem among Chinese children and adolescents with hearing impairment. These results also highlighted that intervention to promote resilience and coping strategies might be helpful to improve their self-esteem.
通讯机构：
[Yuanyuan Li] K;Key Laboratory of Environment and Health (Huazhong University of Science and Technology), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
摘要：
<jats:title>Abstract</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>To identify the intention of Chinese pregnant women to undertake physical activity (PA) using the theory of planned behaviour.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>A cross‐sectional survey.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>From April – October 2017, a cross‐sectional questionnaire was completed by 746 pregnant women from the Health Birth Cohort in Wuhan, China. The theory of planned behaviour variables as well as sociodemographic characteristics was recorded, and the Pregnancy PA Questionnaire was together used to assess their PA during pregnancy.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Only 11.3% of the women met the international guideline. The intention to undertake PA was found it to be positive in 63.9% of pregnant women. Structural equation modelling analysis revealed that behavioural attitudes, subjective norms, and perceived behavioural control (PBC) influenced PA by directly influencing the behaviour intention. Both behavioural attitude and subjective norms influenced PA by indirectly affecting the behaviour. Overall, the model described 60% variance of the behavioural intention to undertake PA during pregnancy.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>PBC was confirmed to be a prominent factor in determining behavioural intention to undertake PA during pregnancy. Pregnant women should be helped and appropriately guided by health providers to overcome barriers to PA.</jats:p></jats:sec><jats:sec><jats:title>Effect</jats:title><jats:p>This study investigates the effect of perceived behavioural control (PBC) on the intention to undertake physical activity (PA). The findings suggest that nurses’ and midwives’ attention should be focused on how to promote the improvement of perceived behavioural control ability of pregnant women to improve pregnant women's PA intention. The attitude of pregnant women on taking up PA and their ability to control behaviours can be improved with support from family or healthcare providers.</jats:p></jats:sec>
摘要：
The prevalence of, and related factors to, stress urinary incontinence (SUI) among perimenopausal Chinese women and its impact on daily life among those women with sexual desire problem in Hubei province were investigated. In this study, 1519 perimenopausal women aged 40 to 65 years were selected from three urban communities in the Wuhan area, and two impoverished, mountainous communities in Hubei province, and followed from April to October 2014. Detailed information about demographic characteristics, menstruation, pregnancy, sexual life and chronic diseases was collected. A cross-sectional survey was carried out following information collection by Chi-square test and multiple logistic regression analysis. Univariate and multivariate logistic regression analysis demonstrated that the potential factors associated with developing SUI were old age (OR=3.4, 95% CI: 1.92–6.04), vaginal delivery (OR=0.623, 95% CI: 0.45–0.87), low income (OR=0.063, 95% CI: 0.40–0.92), atrophic vaginitis (OR=1.4, 95% CI: 1.03–1.80), pelvic organ prolapse (OR=2.81, 95% CI: 1.36–5.80), chronic pelvic pain (OR=2.17, 95% CI: 1.90–4.03), constipation (OR=1.44, 95% CI: 1.07–1.93) and incontinence of feces (OR=3.32, 95% CI: 2.03–5.43). Moreover, the ratio of SUI (33.2%) was higher than the ratio of urgency urinary incontinence (24.1%) or the ratio of mixed urinary incontinence (17.4%), and SUI had a greater impact on daily life among women with decreased sexual desire. In conclusion, SUI is a common disorder affecting over one third of the women surveyed, and has a severe impact on the daily life of perimenopausal women with declined sexual desire. Age, mode of delivery, and monthly income are major risk factors involved in the development of SUI.
期刊：
Proceedings of the 2019 5th International Conference on Humanities and Social Science Research (ICHSSR 2019),2019年:524-527
作者机构：
College of Health Science and Nursing,Wuhan Polytechnic University
会议名称：
2019 5th International Conference on Humanities and Social Science Research （ICHSSR 2019）
会议时间：
2019-04-26
会议地点：
中国广西桂林
会议论文集名称：
Proceedings of 2019 5th International Conference on Humanities and Social Science Research (ICHSSR 2019)（Advances in Social Science, Education and Humanities Research，VOL.319）
摘要：
Health transition and birth quality of pregnant women are associated with pregnancy outcome.Current research has been shown that appropriate physical activity during pregnancy could improve pregnancy outcomes in pregnant women, which was also beneficial for fetuses.In this review, we will discuss the effects of physical activity involved in pregnancy outcomes and their potential association with clinical care during pregnancy.
关键词：
Associating factors;Pregnant women;Urinary metal concentrations
摘要：
Pregnant women, a vulnerable population, can be exposed to a variety of environmental metals that may adversely affect their health at elevated concentrations. Moreover, environmental exposure and risk disparities are associated with several factors such as sociodemographic characteristics, pregnancy complications, and nutritional supplementation indicators. Our aim was to investigate whether and how the urinary metal concentrations vary according to these factors in a large pregnancy and birth cohort. Urinary levels of seven metals including manganese, zinc, selenium, arsenic, cadmium, thallium, and lead were assessed in 7359 participants across Wuhan City in China. In all, 7359 urine samples from the third trimester were analyzed and 15 sociodemographic characteristics, pregnancy complications, and nutritional supplementation indicators were assessed: maternal age, household income, multivitamin supplements during pregnancy, etc. Concentrations of Zn, As, and Cd were detected in all urine samples; Mn, Se, Tl, and Pb were detected in 95.3%, 99.8%, 99.8%, and 99.9% urine samples, respectively. The geometric mean (GM) of creatinine-adjusted urinary Mn, Zn, Se, As, Cd, Tl, and Pb concentrations were 1.42, 505.44, 18.24, 30.49, 0.64, 0.55, and 3.69 mug/g. Factors that associated with environmental metals concentration were as follows: (1) Urinary Zn and Cd concentrations increased with maternal age. (2) Pregnant women with higher education had lower Cd concentrations. (3) Pregnant women with folic acid supplementation had lower Mn and with multivitamin supplementation had higher Se and lower Tl. Our results demonstrated that the maternal age, education level, folic acid supplementation, and multivitamin supplementation were significantly associated with environmental metal concentrations. Furthermore, studies are recommended to explore the influence of diet on biological metals concentrations in more detail.
