作者机构：
[Zhang, Rui; Wu, Muci; Ma, Yan; He, Jingren] Wuhan Polytech Univ, Natl R&D Ctr Se Rich Agr Prod Proc, Sch Modern Ind Selenium Sci & Engn, Wuhan 430048, Peoples R China.;[Zhang, Rui; Wu, Muci; Ma, Yan; He, Jingren] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430048, Peoples R China.;[Li, Ao] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China.;[Wang, Jingyi] Hubei Univ Technol, Sch Food & Biol Engn, Wuhan 430068, Peoples R China.
通讯机构：
[Rui Zhang; Jingren He] N;National R&D Center for Se-Rich Agricultural Products Processing, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430048, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan Polytechnic University, Wuhan 430048, China
摘要：
Oxovitisins are a unique group of anthocyanin derivatives with a non-oxonium nature and α-pyranone (lactone) D ring on the structure. In this study, oxovitisin A was synthesized through the micro-oxidative reaction of carboxypyranomalvidin-3-O-glucoside (vitisin A) with water, and its thermostability, pH, and SO(2) color stability were studied compared with its two precursors, malvidin-3-O-glucoside (Mv3glc) and vitisin A, as well as methylpyrano-malvidin-3-O-glucoside (Me-py). Results showed that oxovitisin A exhibited the highest stabilities, which were inseparably related to its noncharged structure and the additional carbonyl group on the D ring. Moreover, the antiproliferative capacity of oxovitisin A was comparatively evaluated against two human gastrointestinal cancer cell lines. Interestingly, oxovitisin A presented the strongest antiproliferative ability on MKN-28 (IC(50) = 538.42 ± 50.06 μM) and Caco-2 cells (IC(50) = 434.85 ± 11.87 μM) compared with two other pyranoanthocyanins. Therefore, we conclude that oxovitisin A as a highly stable anthocyanin derivative still exhibits a satisfactory antiproliferative ability.
摘要：
Lotus root (Nelumbo nucifera G.) is a high economic value crop in the world. In this study, the storage characteristics (color, sensory, texture, and fatty acids) of lotus root ("Elian No.5") were evaluated at different harvest periods (September 2018, October 2018, November 2018, December 2018, and January 2019). Moreover, the storage characteristics were evaluated after the shortterm and long-term storage of lotus root at 4 degrees C and 20 degrees C. The hardness of lotus root significantly decreased at both temperatures (4 degrees C and 20 degrees C) during the first 3 days of storage. In contrast, the decrease in hardness delayed at 4 degrees C (beyond 3 days of storage). Further, genes related to hardness at different storage temperatures were identified using the RNA-seq and qRT-PCR. The results of this study provide a reference for lotus root storage and a basis for the molecular breeding of longterm-storable lotus root.
通讯机构：
[Nianjie Feng] K;[Liang Zhang] S;Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratoy of Industrial Microbiology, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Research Center of Food Fermentation Engineering and Technology, Hubei University of Technology, Wuhan, Hubei 430068, China<&wdkj&>School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan, Hubei 430068, China<&wdkj&>State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, 130 Chang jiang West Road, Hefei, Anhui 230036, China
关键词：
catechin;gastrointestinal digestion;advanced glycation end products (AGEs);glycopeptides
摘要：
Glycated proteins are the main source of dietary advanced glycation end products (AGEs). Glycated proteins are enzymatically hydrolyzed in the gastrointestinal tract, which releases more absorbable and smaller potentially harmful AGEs. This study investigated the inhibitory effect of catechin on AGE release from glycated bovine serum albumin (G-BSA) during gastrointestinal digestion. Catechin inhibited AGE release during gastrointestinal digestion, especially in the gastric digestion stage. Additionally, catechin altered these peptides in the small intestine by reducing G-BSA digestibility. The proposed mechanism involves interactions between catechin and G-BSA/digestive enzymes, inhibiting digestive enzyme activity and changing the conformation of G-BSA. Catechin reduced G-BSA β-sheet content and protected the helical conformation. Moreover, catechin enhanced the antioxidant capacity of G-BSA, which could attenuate postprandial oxidative stress in the gastrointestinal tract caused by the release of AGEs. This study improves our understanding of the nutritional and health effects of catechin on dietary AGEs during gastrointestinal digestion.
期刊：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2021年69(32):9102-9110 ISSN：0021-8561
通讯作者：
Wenjing Huang<&wdkj&>Gaofu Qi<&wdkj&>Gan Lu<&wdkj&>Xiangliang Yang
作者机构：
College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, Hubei 430023, People’s Republic of China;[Lang, Yan; Lu, Gan; Yang, Xiangliang] National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People’s Republic of China;[Zeng, Zhujun; Qi, Gaofu] College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People’s Republic of China;[Xiang, Xia] Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Wuhan, Hubei 430062, People’s Republic of China;[Huang, Wenjing] College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, Hubei 430023, People’s Republic of China<&wdkj&>National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People’s Republic of China
通讯机构：
[Wenjing Huang; Gaofu Qi] C;[Gan Lu; Xiangliang Yang] N;College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, Hubei 430023, People’s Republic of China<&wdkj&>National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People’s Republic of China<&wdkj&>National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People’s Republic of China<&wdkj&>College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, People’s Republic of China
会议名称：
5th International Symposium on Lipid Science and Health (ISLSH)
摘要：
In recent decades, epidemiological, clinical, and experimental studies have demonstrated that a diet with antioxidant or anti-inflammatory function plays a central role in the prevention of atherosclerosis (AS). The purpose of this study was to explore the effects of Cannabis seed oil (CO) administration on in vitro antioxidant capacity as well as blood lipid profiles, lipid peroxidation, inflammatory response, and endothelial cell integrity. Female ApoE(-/-) mice were fed a high-cholesterol diet and administrated with CO or phosphate-buffered saline (PBS) and seal oil by gavage for 8 weeks. The results show that CO administration reduced the levels of serum triglycerides and low-density lipoprotein cholesterol at week 6. Additionally, a decrease in serum tumor necrosis factor α and nitric oxide was also observed. Moreover, results from CD31 staining and scanning electron microscopy revealed that CO treatment alleviated the endothelial cell damage and lipid deposition induced by a high-cholesterol diet. The ratio of lesion area to the total aorta area was 19.57% for the CO group, which was lower than the PBS control group (24.67%). Collectively, CO exerted anti-atherosclerotic effects by modulating serum lipid profiles and inflammatory responses and improving endothelial cell integrity and arterial lipid deposition. The results provide a promising preventive strategy for the early progression of AS.
作者机构：
[Cai, Jie; Cheng, Shui-Yuan; Zhang, Die; He, Jing-Ren] Wuhan Polytech Univ, Natl R&D Ctr Se Rich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Se Rich Agr Pr, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.;[Cai, Jie; Chen, Lei; Dong, Qi; Wang, Guo-Zhen; Zhang, Die; Hu, Zhong-Ze; Ding, Wen-Ping] Wuhan Polytech Univ, Key Lab Deep Proc Major Grain & Oil, Hubei Key Lab Proc & Transformat Agr Prod, Minist Educ, Wuhan 430023, Peoples R China.;[Din, Zia-ud] Univ Swabi, Dept Agr, Anbar 23561, Khyber Pakhtunk, Pakistan.
通讯机构：
[Jie Cai] N;National R&D Center for Se-rich Agricultural Products Processing, Hubei Engineering Research Center for Deep Processing of Green Se-rich Agricultural Products, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, PR China<&wdkj&>Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan Polytechnic University, Wuhan 430023, PR China
通讯机构：
[Xuefeng Zeng] S;School of Liquor and Food Engineering, Guizhou University, Guiyang, China<&wdkj&>Guizhou Provincial Key Laboratory of Agricultural and Animal Products Storage and Processing, Guiyang, China<&wdkj&>Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region, Ministry of Education, Guiyang, China
通讯机构：
[Liming Cheng] D;Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China
摘要：
The variations and dynamics of essential and toxic metal(loid)s in patients with COVID-19 may associate with the progression and fatal outcome of the disease, which still remains to investigate. In the present study, a retrospective analysis was performed in a cohort of 306 confirmed COVID-19 patients admitted to Tongji hospital (Wuhan, China) from February 10 to March 15, 2020. Whole blood levels of essential and/or toxic metal(loid)s were analyzed, including magnesium, calcium, chromium, manganese, iron, copper, zinc, arsenic, cadmium, mercury, thallium, and lead according to the disease severity and outcome. Compared to the non-severe COVID-19 patients, severe cases showed significant higher levels of whole blood calcium, chromium, and copper, but lower levels of magnesium, manganese, iron, zinc, arsenic, thallium, and lead. These differences were further found consistently across the clinical course since the disease onset by longitudinal analysis. Among the severe patients, chromium and cadmium were higher in the deceased group compared to the recovered group, while arsenic was lower. Whole blood iron, age, and sex were determined to be independent factors associated with the disease severity, while chromium, cadmium, and the comorbidity of cardiovascular disease were determined to be independent factors associated with the mortality. These results suggest that variations of whole blood metal(loid)s may be associated with the severe illness and fatal outcome of COVID-19, which could be persistently monitored and would be helpful in the evaluation of the dynamic changes in patients with COVID-19.
通讯机构：
[Nianjie Feng] K;Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratoy of Industrial Microbiology, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Research Center of Food Fermentation Engineering and Technology, Hubei University of Technology, Wuhan, Hubei 430068, China<&wdkj&>School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan, Hubei 430068, China
关键词：
(+)-catechin (CC);Absorption;Advanced glycation end products (AGEs);Cytotoxicity;Peptide-bound AGEs
摘要：
Longan polysaccharides are valuable compounds with many biological activities. Lactobacillus fermentum was selected to ferment longan pulp and the polysaccharides from unfermented and fermented longan pulp (denoted as LP and LP-F, respectively) were isolated. Their physicochemical, immunomodulatory and prebiotic activities were investigated. The results revealed that LP-F, the molecular weight of which was lower than that of LP, contained less neutral sugar, uronic acid and glucose but more arabinose, galactose, rhamnose and mannose. Compared with LP, LP-F had better solubility, lower apparent viscosity and particle size. LP-F exhibited stronger stimulation on macrophages secretion of NO and IL-6, as well as better proliferation of Leuconostoc mesenteroides and Lactobacillus casei. In summary, fermentation treatment could change the physicochemical properties and enhance the bioactivity of polysaccharides from longan pulp. (C) 2018 Published by Elsevier B.V.
摘要：
Tannin-supported on cellulose (TM) microfibers were successfully prepared to remove cationic dye in aqueous solution. SEM and mechanical tests were employed to characterize their structures and properties. Methylene blue (MB) as a cationic organic dye was applied to estimate the adsorption ability of TM microfibers. The network structure of TM microfibers, and electrostatic attractions between tannins and MB molecules attribute to the good adsorption. TM fibers have higher adsorption capacity at higher pH. The Q(max) of TM fibers is 31.7 mg/g at 333 K. Thermodynamic analysis demonstrated that the adsorption process was spontaneous and favorable. Adsorption-desorption experiments demonstrated that TM microfibers possessed excellent stability and reusable ability. The pseudo-second-order and Langmuir isotherm model could better describe the adsorption behaviors of TM microfibers. The adsorption-desorption experiments of TM microfibers were recycled 5 times with no obvious decrease of adsorption capacity. Tannins supported on TM serve as binding sites to combine MB through electrostatic attractions, making for the excellent adsorption effect of TM microfibers. This work provides a novel method to fabricate tannin-supported materials for sewage treatment. (C) 2019 Elsevier B.V. All rights reserved.
